Evidence map›Paper›PMID 38822196›Full record

ArticleJournal of neurovirology2024

Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV.

Kimberly S Williams, Jaimie A Seawell, Viktoriya Zhuravleva, Kersten Pierre, Rick B Meeker

Abstract read
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In one paragraph

Article in Journal of neurovirology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kimberly S WilliamsEnvironmental and Health Sciences Program, Spelman College, 30314, Atlanta, GA, USA. kwilli43@spelman.edu.ORCID 0000-0001-7014-0955
Jaimie A SeawellDepartment of Neurology, University of North Carolina, 27599, Chapel Hill, NC, USA.
Viktoriya ZhuravlevaDepartment of Neurology, University of North Carolina, 27599, Chapel Hill, NC, USA.ORCID 0000-0002-3515-4945
Kersten PierreEnvironmental and Health Sciences Program, Spelman College, 30314, Atlanta, GA, USA.
Rick B MeekerDepartment of Neurology, University of North Carolina, 27599, Chapel Hill, NC, USA.ORCID 0000-0002-7487-5315

Funding

Neurotrophin mimetic therapeutics for HIV-associated neural dysfunctionR01MH085606 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2009 to 2013
$1.7M
Neurotrophin Protection in HIV and AgingR01NS083164 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEEKER, RICK B · 2013 to 2016
$1.1M
Neurotrophin- Chemokine Receptor Interactions Regulate Macrophage ActivationF31MH101019 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAMS, KIMBERLY S. · 2013 to 2014
$65k
NIH HHS F31 MH101019NIH HHS R01 MH085606NINDS NIH HHS R01 NS083164
6 · The paper itself

Abstract

Neural damage due to inflammatory activation of macrophages and microglia is a consequence of HIV infection that leads to cognitive dysfunction. The damage is due, in part, to the release of factors that impair neuronal function but the mechanisms that control their release are poorly understood. Previous studies have shown that mature nerve growth factor (NGF) binding to tropomyosin receptor kinase A (TrkA), and proNGF acting through the p75 neurotrophin receptor (p75

Indexed as

HIV-1MacrophagesReceptors, CXCR4Receptors, Nerve Growth FactorReceptor, trkACells, CulturedHIV InfectionsHumansMacrophage ActivationNerve Tissue ProteinsPhenotypePhosphorylationSignal TransductionCXCR4 protein, humanNerve Tissue ProteinsNGFR protein, humanNTRK1 protein, humanReceptors, CXCR4Receptors, Nerve Growth FactorReceptor, trkAChemokinesNeuroAIDSNeurodegenerationNeuroinflammation

Identifiers

PMID38822196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.