Evidence map›Paper›PMID 38822175›Full record

ArticleVirchows Archiv : an international journal of pathology2024

Paediatric pancreatic acinar cell carcinoma with a novel SEC31A-BRAF fusion gene.

Tingting Li, Yin Cheng, Yixuan Han, Li Yang, Qiang Wei, Xiaosong Yan, Yue Shi, Xin Zhang, Meng Yang, Yanfei Liu

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingting Li *Department of Pathology, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Yin Cheng *Departments of Pathology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Yixuan HanSecond School of Clinical Medicine, Xi'an Medical University, Xi'an, 710003, Shaanxi, China.
Li YangDepartment of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.
Qiang WeiDepartment of General Surgery, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Xiaosong YanDepartment of Pathology, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Yue ShiDepartment of Pathology, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Xin ZhangDepartment of Pathology, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Meng YangDepartment of Medical Imaging, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China.
Yanfei LiuDepartment of Pathology, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, Shaanxi, China. Liu18182429139@163.com.ORCID http://orcid.org/0000-0003-3624-2717

Funding

shaanxi province key R&D Program General Project in the field of social development 2022SF-257Xi'an innovation abillity strong foundation Program Medical research Project 21YXYJ0012
6 · The paper itself

Abstract

Paediatric pancreatic acinar cell carcinoma (PACC) presents a diagnostic challenge, often confused with pancreatoblastoma (PB) due to its rarity. It is crucial to differentiate between PB and PACC, given their distinct therapeutic strategies and prognoses. Histologically, the absence of squamoid nests and scarcity of tumor mesenchyme support PACC. Conversely, the identification of a BRAF alteration leans towards PACC. Here, we present the case of an 8-year-old girl with a well-defined mass in the pancreas. The tumor exhibited a SEC31A-BRAF fusion gene and amplification of 18p, showcasing unequivocal acinar differentiation and a minor degree of neuroendocrine differentiation. Additionally, the tumor displayed scant fibrous stroma, and an absence of squamoid nests, further supporting PACC. Notably, this is the first reported instance of a solid tumor featuring a SEC31A-BRAF gene fusion. The discovery of this novel fusion gene expands our understanding of BRAF fusion partner profiles, particularly in the context of paediatric PACC.

Indexed as

Carcinoma, Acinar CellPancreatic NeoplasmsProto-Oncogene Proteins B-rafBiomarkers, TumorChildFemaleHumansOncogene Proteins, FusionSEC Translocation ChannelsBiomarkers, TumorBRAF protein, humanOncogene Proteins, FusionProto-Oncogene Proteins B-rafSEC Translocation ChannelsBRAF rearrangementPancreatic acinar cell carcinomaPancreatoblastoma

Identifiers

PMID38822175

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.