Evidence map›Paper›PMID 38821959›Full record

ArticleNature communications2024

In-situ observation of silk nanofibril assembly via graphene plasmonic infrared sensor.

Chenchen Wu, Yu Duan, Lintao Yu, Yao Hu, Chenxi Zhao, Chunwang Ji, Xiangdong Guo, Shu Zhang, Xiaokang Dai, Puyi Ma and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chenchen Wu *CAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China.
Yu Duan *CAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China.
Lintao YuSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China.ORCID http://orcid.org/0000-0002-9852-5993
Yao HuDepartment of Physics, University of Science and Technology of China, Hefei, Anhui, 230026, China.
Chenxi ZhaoSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Chunwang JiCAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China.
Xiangdong GuoCAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China.
Shu ZhangCAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China.
Xiaokang DaiCAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China.
Puyi MaCAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China.
Qian WangDepartment of Physics, University of Science and Technology of China, Hefei, Anhui, 230026, China. wqq@ustc.edu.cn.ORCID http://orcid.org/0000-0002-9908-4317
Shengjie LingSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China. lingshj@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0003-1156-0479
Xiaoxia YangCAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China. yangxx@nanoctr.cn.ORCID http://orcid.org/0000-0002-0670-053X
Qing DaiCAS Key Laboratory of Nanophotonic Materials and Devices, National Center for Nanoscience and Technology, Beijing, 100190, China. daiq@nanoctr.cn.ORCID http://orcid.org/0000-0002-1750-0867

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21935002National Natural Science Foundation of China (National Science Foundation of China) 32000882National Natural Science Foundation of China (National Science Foundation of China) 51925203National Natural Science Foundation of China (National Science Foundation of China) 51972074National Natural Science Foundation of China (National Science Foundation of China) 52022025National Natural Science Foundation of China (National Science Foundation of China) 52102160National Natural Science Foundation of China (National Science Foundation of China) 52322305National Natural Science Foundation of China (National Science Foundation of China) U2032206
6 · The paper itself

Abstract

Silk nanofibrils (SNFs), the fundamental building blocks of silk fibers, endow them with exceptional properties. However, the intricate mechanism governing SNF assembly, a process involving both protein conformational transitions and protein molecule conjunctions, remains elusive. This lack of understanding has hindered the development of artificial silk spinning techniques. In this study, we address this challenge by employing a graphene plasmonic infrared sensor in conjunction with multi-scale molecular dynamics (MD). This unique approach allows us to probe the secondary structure of nanoscale assembly intermediates (0.8-6.2 nm) and their morphological evolution. It also provides insights into the dynamics of silk fibroin (SF) over extended molecular timeframes. Our novel findings reveal that amorphous SFs undergo a conformational transition towards β-sheet-rich oligomers on graphene. These oligomers then connect to evolve into SNFs. These insights provide a comprehensive picture of SNF assembly, paving the way for advancements in biomimetic silk spinning.

Identifiers

PMID38821959
PMCPMC11143229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.