Evidence map›Paper›PMID 38821853›Full record

ArticleTrends in cancer2024

COX2-dependent suppression of anticancer immunity.

María Cecilia Lira, Lorenzo Galluzzi, Claire Vanpouille-Box

Abstract read
In one paragraph

Article in Trends in cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Celecoxib in oncology: targeting the COX-2/PGEFrontiers in pharmacology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

María Cecilia LiraDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.
Claire Vanpouille-BoxDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA. Electronic address: clv2002@med.cornell.edu.

Funding

Radiation Effect on Immune Cells and the MicrobiomeU54CA274291 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joseph O Deasy · 2022 to 2026
$9.1M
Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancerR01CA271915 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Lorenzo Galluzzi · 2023 to 2026
$2.9M
Fatty Acid Metabolic Regulation of Anti-Tumor Immunity Against Irradiated GlioblastomaR01NS131945 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Claire Isabelle Vanpouille-Box · 2023 to 2026
$2.2M
Role of FAP-positive cells in immune response to irradiated glioblastomaR21CA280787 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI VANPOUILLE-BOX, CLAIRE ISABELLE · 2023 to 2024
$426k
NCI NIH HHS R01 CA271915NCI NIH HHS R21 CA280787NCI NIH HHS U54 CA274291NINDS NIH HHS R01 NS131945
6 · The paper itself

Abstract

Prostaglandin E

Indexed as

Cyclooxygenase 2DinoprostoneMitochondriaNeoplasmsAnimalsHumansReceptors, Interleukin-2T-LymphocytesCyclooxygenase 2DinoprostoneReceptors, Interleukin-2apoptosisCASP3NK cellsPTGER2radiation therapytumor-infiltrating lymphocyte

Identifiers

PMID38821853
PMCPMC11236508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.