Evidence map›Paper›PMID 38821554›Full record

ArticleStroke and vascular neurology2025

Left atrial appendage closure for patients with atrial fibrillation at high intracranial haemorrhagic risk.

Avia Abramovitz Fouks, Shadi Yaghi, Elif Gokcal, Alvin S Das, Ofer Rotschild, Scott B Silverman, Aneesh B Singhal, Jorge Romero, Sunil Kapur, Steven M Greenberg and 1 more

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In one paragraph

Article in Stroke and vascular neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Avia Abramovitz FouksNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0009-0005-7483-8193
Shadi YaghiNeurology, Brown University, Warren Alpert Medical School, Providence, RI, USA.
Elif GokcalNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Alvin S DasNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2313-977X
Ofer RotschildNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Scott B SilvermanNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Aneesh B SinghalNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Jorge RomeroDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sunil KapurDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Steven M GreenbergNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA.
Mahmut Edip GurolNeurology, Massachussets General Hospital, Harvard Medical School, Boston, MA, USA MEGUROL@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesAlthough left atrial appendage closure (LAAC) is performed in patients with non-valvular atrial fibrillation (NVAF) at increased risk of intracranial haemorrhage (ICH), outcome data are scarce. We assessed the detailed neurological indications for LAAC and outcomes after LAAC in high ICH risk patients.

methodsStudy population included consecutive patients with NVAF who underwent LAAC in a single hospital network between January 2015 and October 2021 because of prior ICH or the presence of high ICH risk imaging markers on brain MRI (cerebral microbleeds (CMBs)). Primary safety and efficacy outcome measures were the occurrence of ICH and thromboembolic events, respectively, after LAAC.

resultsAmong 146 patients with NVAF who underwent LAAC for high ICH risk, 122 had a history of ICH, while 24 presented with high ICH risk imaging markers only. Mean age was 75.7±7.61, 42 (28.8%) were women. Mean CHA

conclusionsAmong patients with NVAF at high ICH risk, LAAC demonstrated a low risk of recurrent ICH or ischaemic stroke compared with previously published data. LAAC in high ICH risk populations should be considered in clinical practice per FDA approval and recent guidelines.

Indexed as

Atrial AppendageAtrial FibrillationCardiac CatheterizationCardiac Surgical ProceduresIntracranial HemorrhagesAgedAged, 80 and overFemaleHumansLeft Atrial Appendage ClosureMaleRetrospective StudiesRisk AssessmentRisk FactorsThromboembolismTime FactorsAnticoagulantsAtrial FibrillationHemorrhageStroke

Identifiers

PMID38821554
PMCPMC11877437

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