Evidence map›Paper›PMID 38821318›Full record

ArticleThe Journal of allergy and clinical immunology2024

Saliva antibody profiles are associated with reaction threshold and severity of peanut allergic reactions.

Hsi-En Ho, Zoe Arditi, Lin Radigan, Galina Grishina, Lingdi Zhang, Yoojin Chun, Tracy Lo, Julie Wang, Scott Sicherer, Supinda Bunyavanich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hsi-En HoDivision of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Zoe ArditiDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Lin RadiganDivision of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Galina GrishinaDivision of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
Lingdi ZhangDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Yoojin ChunDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.
Tracy LoDivision of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
Julie WangDivision of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
Scott SichererDivision of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
Supinda BunyavanichDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY; Division of Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: supinda@post.harvard.edu.

Funding

Threshold, Severity, and Immunotherapy of Peanut AllergyU19AI136053 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUNYAVANICH, SUPINDA · 2018 to 2023
$9.1M
Gut Microbiome Dynamics in Peanut AllergyR01AI147028 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BUNYAVANICH, SUPINDA · 2019 to 2022
$3.3M
NIAID NIH HHS R01 AI147028NIAID NIH HHS U19 AI136053
6 · The paper itself

Abstract

backgroundReaction threshold and severity in food allergy are difficult to predict, and noninvasive predictors are lacking.

objectiveWe sought to determine the relationships between pre-challenge levels of peanut (PN)-specific antibodies in saliva and reaction threshold, severity, and organ-specific symptoms during PN allergic reactions.

methodsWe measured PN-specific antibody levels in saliva collected from 127 children with suspected PN allergy before double-blind, placebo-controlled PN challenges in which reaction threshold, severity, and symptoms were rigorously characterized. Low threshold (LT) PN allergy was defined as reaction to <300 mg of PN protein cumulatively consumed. A consensus severity grading system was used to grade severity. We analyzed associations between antibody levels and reaction threshold, severity, and organ-specific symptoms.

resultsAmong the 127 children, those with high pre-challenge saliva PN IgE had higher odds of LT PN allergy (odds ratio [OR] 3.9, 95% CI 1.6-9.5), while those with high saliva PN IgA:PN IgE ratio or PN IgG

conclusionsSaliva PN antibodies could aid in noninvasive risk stratification of PN allergy threshold, severity, and organ-specific symptoms.

Indexed as

Immunoglobulin EPeanut HypersensitivitySalivaSeverity of Illness IndexAdolescentAllergensArachisChildChild, PreschoolDouble-Blind MethodFemaleHumansImmunoglobulin AImmunoglobulin GMaleAllergensImmunoglobulin AImmunoglobulin EImmunoglobulin Gallergyantibodyendotypefood allergynoninvasivePeanutreactionsalivaseveritysymptomthreshold

Identifiers

PMID38821318
PMCPMC11380589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.