Evidence map›Paper›PMID 38821188›Full record

Observational studyJournal of vascular surgery. Venous and lymphatic disorders2024

Varicose vein surgery after acute isolated superficial vein thrombosis in daily practice: INSIGHTS-SVT study.

Thomas Noppeney, Eberhard Rabe, Ulrich Hoffmann, Alexandra Schimke, Andreas Heinken, Florian Langer, David Pittrow, Jens Klotsche, Horst E Gerlach, Rupert Bauersachs and 1 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of vascular surgery. Venous and lymphatic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thomas NoppeneyDepartment for Vascular and Endovascular Surgery, University Hospital Regensburg, Regensburg, Germany. Electronic address: tnoppeney@outlook.de.
Eberhard RabePrivate Practice Dermatology and Phlebology, Bonn, Germany.
Ulrich HoffmannDivision of Vascular Medicine, Medical Clinic and Policlinic IV, Ludwig-Maximilian University, Munich, Germany.
Alexandra SchimkeMedical Affairs, Mylan Germany GmbH, Bad Homburg, Germany.
Andreas HeinkenMedical Affairs, Amgen GmbH, Munich, Germany.
Florian LangerII. Medical Clinic and Policlinic, Center for Oncology, University Medical Center Eppendorf, Hamburg, Germany.
David PittrowInstitute for Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany.
Jens KlotscheInnovation Center Real-World Evidence, GWT-TUD GmbH, Dresden, Germany; Epidemiology and Health Services Research, Deutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz-Gemeinschaft, Berlin, Germany.
Horst E GerlachPrivate Practice for Vascular Diseases, Viernheim, Germany.
Rupert BauersachsCenter for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany; Cardioangiologisches Centrum Bethanien CCB, Standort AGAPLESION Bethanien Krankenhaus, Frankfurt am Main, Germany.
INSIGHTS-SVT study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to assess the utilization of surgical interventions in patients diagnosed with superficial vein thrombosis (SVT) and its potential association with the occurrence of venous thromboembolism (VTE) and bleeding events.

methodsINSIGHTS-SVT, a prospective, non-interventional, multicenter study in Germany, investigated the management and outcomes of patients with acute SVT who received conservative and/or invasive treatments at the discretion of the treating physician.

resultsAmong the 872 patients with 12-month data, 657 had medical therapy only, and 215 patients underwent vascular surgery (70 within 3 months of SVT diagnosis, 136 between months 4 and 12, and nine had an intervention in both periods). The most commonly performed procedures included endovenous thermal ablation, ligation of the saphenofemoral or saphenopopliteal junction, and vein stripping. The primary outcome of symptomatic VTE was observed in 5.8% of conservatively treated patients and 6.3% of those who underwent surgical intervention. Additionally, the secondary outcome of recurrent or extended SVT was documented in 4.7% of conservatively treated patients and 5.3% of invasively treated patients. Bleeding events occurred in 1.4% of conservatively treated patients and 2.1% of surgically treated patients. These differences were statistically not significant. Furthermore, our analysis indicated a potential protective effect associated with surgical treatments, such as ligation of the saphenofemoral or saphenopopliteal junction, stripping and endovenous thermal ablation, concerning the endpoint of VTE for patients when applied after 3 months from the index SVT event.

conclusionsIn line with previous research, our study suggests that surgical interventions are not frequently employed in the management of SVT, although they may be warranted in select cases. Nevertheless, additional research is essential to gain a deeper understanding of the indications, criteria, and benefit of surgical interventions in the treatment of SVT.

Indexed as

Varicose VeinsVenous ThrombosisAcute DiseaseAdultAgedConservative TreatmentFemaleGermanyHemorrhageHumansMaleMiddle AgedPractice Patterns, Physicians'Prospective StudiesRecurrenceRisk FactorsFondaparinuxLow-molecular weight heparinPrognosisRisk assessmentSuperficial vein thrombosisSurgical interventionVenous thrombosis

Identifiers

PMID38821188
PMCPMC11523306

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.