Evidence map›Paper›PMID 38820770›Full record

ArticleNeurobiology of aging2024

Cognitive reserve proxies are associated with age-related cognitive decline - Not age-related gait speed decline.

Helena M Blumen, Oshadi Jayakody, Emmeline Ayers, Nir Barzilai, Christian Habeck, Sofiya Milman, Yaakov Stern, Erica F Weiss, Joe Verghese

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Helena M BlumenDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: helena.blumen@einsteinmed.edu.
Oshadi JayakodyDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Emmeline AyersDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Nir BarzilaiDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
Christian HabeckDepartment of Neurology, Columbia University, New York, NY, USA.
Sofiya MilmanDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Yaakov SternDepartment of Neurology, Columbia University, New York, NY, USA.
Erica F WeissDepartment of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Joe VergheseDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

Funding

The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center studyR01AG057548 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI VERGHESE, JOE · 2020 to 2024
$8.0M
Resilience to Alzheimer's disease in humans with exceptional longevityR01AG057909 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J, ZHANG, ZHENGDONG · 2017 to 2021
$6.2M
Somatotropic Signaling and Resilience to Aging and Alzheimer's DiseaseR01AG061155 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MILMAN, SOFIYA · 2019 to 2023
$4.3M
Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementiaR01AG062659 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BLUMEN, HELENA M · 2020 to 2024
$3.8M
NIA NIH HHS R01 AG057548NIA NIH HHS R01 AG057909NIA NIH HHS R01 AG061155NIA NIH HHS R01 AG062659
6 · The paper itself

Abstract

Cognition and gait share brain substrates in aging and dementia. Cognitive reserve (CR) allows individuals to cope with brain pathology and delay cognitive impairment and dementia. Yet, evidence for that CR is associated with age-related cognitive decline is mixed, and evidence for that CR is associated with age-related gait decline is limited. In 1,079 older (M Age = 75.4 years; 56.0% women) LonGenity study participants without dementia at baseline and up to 12 years of annual follow-up (M follow-up = 3.9 years, SD = 2.5 years), high CR inferred from cognitive (education years), physical (number of blocks walked per day; weekly physical activity days), and social (volunteering/working; living with someone) proxies were associated with slower rates of age-related decline in global cognition - not gait speed decline. Thus, cognitive, physical, and social CR proxies are associated with cognitive decline in older adults without dementia. The multifactorial etiology and earlier decline in gait than cognition may render it less modifiable by CR proxies later in life.

Indexed as

AgingCognitive DysfunctionCognitive ReserveWalking SpeedAgedAged, 80 and overCognitionFemaleFollow-Up StudiesGaitHumansMaleBrain maintenanceCognitive declineCognitive reserveFrontal cortical thicknessGait declineHippocampal volume

Identifiers

PMID38820770
PMCPMC12944813

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.