Evidence map›Paper›PMID 38820160›Full record

ArticleScience advances2024

Ribonuclease inhibitor and angiogenin system regulates cell type-specific global translation.

Martina Stillinovic, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Frédéric Greub, Giuseppe Bombaci, Camille Ansermet, Marco Zatti, Dipanjali Saha, Jieyu Xiong and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Martina StillinovicDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0009-0008-7534-7021
Mayuresh Anant SarangdharDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-5653-8991
Nicola AndinaDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-2924-6763
Aubry TardivelDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0009-0008-9997-8151
Frédéric GreubDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0009-0006-1010-9917
Giuseppe BombaciDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-0752-4769
Camille AnsermetDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Marco ZattiDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Dipanjali SahaDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0009-0003-5575-9655
Jieyu XiongDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0009-0007-1443-7042
Takeru SagaeGraduate School of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo, Japan.ORCID 0009-0001-0946-4691
Mariko YokogawaGraduate School of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo, Japan.ORCID 0000-0003-3448-7112
Masanori OsawaGraduate School of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo, Japan.ORCID 0000-0002-1285-4316
Manfred HellerDepartment for BioMedical Research, University of Bern, Bern, Switzerland.ORCID 0000-0002-6364-7325
Adrian KeoghDepartment for BioMedical Research, University of Bern, Bern, Switzerland.ORCID 0000-0003-3390-1633
Irene KellerDepartment for BioMedical Research, University of Bern, Bern, Switzerland.ORCID 0000-0003-2908-8782
Anne Angelillo-ScherrerDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0003-2872-4863
Ramanjaneyulu AllamDepartment of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-2789-3596

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular organisms. Conventionally, it has been considered a default step in gene expression, lacking specific regulation. However, recent studies have documented that certain mRNAs exhibit cell type-specific translation. Despite this, it remains unclear whether global translation is controlled in a cell type-specific manner. By using human cell lines and mouse models, we found that deletion of the ribosome-associated protein ribonuclease inhibitor 1 (RNH1) decreases global translation selectively in hematopoietic-origin cells but not in the non-hematopoietic-origin cells. RNH1-mediated cell type-specific translation is mechanistically linked to angiogenin-induced ribosomal biogenesis. Collectively, this study unravels the existence of cell type-specific global translation regulators and highlights the complex translation regulation in vertebrates.

Indexed as

Protein BiosynthesisRibonuclease, PancreaticRibosomesAnimalsCarrier ProteinsCell LineGene Expression RegulationHumansMiceOrgan SpecificityRNA, MessengerangiogeninCarrier ProteinsRibonuclease, PancreaticRNA, MessengerRNH1 protein, human

Identifiers

PMID38820160
PMCPMC11141627

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.