ArticleScience advances2024
Autonomous assembly and disassembly of gliding molecular robots regulated by a DNA-based molecular controller.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Nanoarchitectonics of molecular machines, biomolecular machines, and microrobots in their collective behaviour.Chemical science · 2026Review
- KLP-6 is a kinesin superfamily protein resistant to ADP inhibition.Communications biology · 2026Article
- Reset-free DNA logic circuits for real-time input processing and memory.Science advances · 2026Article
- DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes.Nature communications · 2025Article
- Nonequilibrium Self-Assembly of Microtubules Through Stepwise Sequential Interactions of DNA.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Optical Control of Microtubule Accumulation and Dispersion by Tau-Derived Peptide-Fused Photoresponsive Protein.JACS Au · 2025Article
- On-Demand Photoactivation of DNA-Based Motor Motion.ACS nano · 2025Article
- Approaching active matter from biophysics perspective.Biophysics and physicobiology · 2025Article
- Design of open systems for meniscus splitting demonstrated using an aqueous polymer solution.Science and technology of advanced materials · 2025Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, there has been a growing interest in engineering dynamic and autonomous systems with robotic functionalities using biomolecules. Specifically, the ability of molecular motors to convert chemical energy to mechanical forces and the programmability of DNA are regarded as promising components for these systems. However, current systems rely on the manual addition of external stimuli, limiting the potential for autonomous molecular systems. Here, we show that DNA-based cascade reactions can act as a molecular controller that drives the autonomous assembly and disassembly of DNA-functionalized microtubules propelled by kinesins. The DNA controller is designed to produce two different DNA strands that program the interaction between the microtubules. The gliding microtubules integrated with the controller autonomously assemble to bundle-like structures and disassemble into discrete filaments without external stimuli, which is observable by fluorescence microscopy. We believe this approach to be a starting point toward more autonomous behavior of motor protein-based multicomponent systems with robotic functionalities.
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