Evidence map›Paper›PMID 38820077›Full record

ArticleThe Journal of infectious diseases2024

Household Transmission and Clinical Features of Respiratory Tract Infections That Were SARS-CoV-2 Positive and Negative.

Jaakko Ahti, Laura Toivonen, Helena Ollila, Lauri Ivaska, Krista Salo-Tuominen, Tytti Vuorinen, Johanna Lempainen, Ville Peltola

Abstract read
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In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jaakko AhtiDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku.ORCID 0000-0002-1593-213X
Laura ToivonenDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku.
Helena OllilaDepartment of Biostatistics, Turku University Hospital and University of Turku.
Lauri IvaskaDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku.
Krista Salo-TuominenDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku.
Tytti VuorinenDepartment of Clinical Microbiology, Turku University Hospital.
Johanna LempainenDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku.
Ville PeltolaDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku.

Funding

Government Research FoundationHospital District of Southwest FinlandMaud Kuistila FoundationPäivikki and Sakari Sohlberg FoundationPaulo FoundationSatakunta Hospital DistrictSpecified Government Transfers
6 · The paper itself

Abstract

backgroundComparative data are limited on the transmission of respiratory infections positive and negative for SARS-CoV-2 in households with children.

methodsIn June to August 2020, we recruited 700 participants (175 households, 376 children, 324 adults) to be prospectively followed for all respiratory tract infections. Follow-up lasted from recruitment until April 2022. Daily symptoms were monitored by weekly electronic questionnaires. SARS-CoV-2 polymerase chain reaction testing from nasopharyngeal specimens was performed for symptomatic participants and twice (1-week interval) for the household members of positive participants. Clinical features and secondary attack rates (SARs) based on the onset of symptoms were compared between respiratory infections that were SARS-CoV-2 positive and negative.

resultsMost SARS-CoV-2 infections (90%) occurred from January to April 2022 when Omicron BA.1 and BA.2 were the dominant variants. SARS-CoV-2-positive infections were transmitted more often than SARS-CoV-2-negative infections (SAR, 41% vs 24%; P < .001). SARS-CoV-2 transmission was similar for child and adult index cases (SAR, 40% vs 43%; P = .47), but the transmission of SARS-CoV-2-negative infections was higher for child index cases (SAR, 27% vs 18%; P < .001).

conclusionsOur findings demonstrate that SARS-CoV-2 Omicron viruses spread more effectively within households as compared with other respiratory infections.

Indexed as

COVID-19Family CharacteristicsRespiratory Tract InfectionsSARS-CoV-2AdolescentAdultAgedChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedNasopharynxProspective StudieschildrenCOVID-19household transmissionSARS-CoV-2secondary attack rate

Identifiers

PMID38820077
PMCPMC11481349

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.