Evidence map›Paper›PMID 38820076›Full record

ArticleAngewandte Chemie (International ed. in English)2024

Roles of Ferric Peroxide Anion Intermediates (Fe

Yasuhiro Tateishi, Kevin D McCarty, Martha V Martin, Francis K Yoshimoto, F Peter Guengerich

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Cytochrome P450The Journal of biological chemistry · 2025
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yasuhiro TateishiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, United States.ORCID https://orcid.org/0000-0003-1884-014X
Kevin D McCartyDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, United States.ORCID https://orcid.org/0000-0003-0027-9120
Martha V MartinDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, United States.
Francis K YoshimotoDepartment of Chemistry, University of Texas at San Antonio, San Antonio, Texas, 78249, United States.ORCID https://orcid.org/0000-0002-2308-2999
F Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, United States.ORCID https://orcid.org/0000-0002-7458-3048

Funding

Metabolism of Carcinogens and Drugs by Human P450sR01GM118122 · NIGMS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2016 to 2023
$3.3M
National Science Foundation 1937963NIGMS NIH HHS R01 GM118122
6 · The paper itself

Abstract

Cytochrome P450 (P450, CYP) 19A1 is the steroid aromatase, the enzyme responsible for the 3-step conversion of androgens (androstenedione or testosterone) to estrogens. The final step is C-C bond scission (removing the 19-oxo group as formic acid) that proceeds via a historically controversial reaction mechanism. The two competing mechanistic possibilities involve a ferric peroxide anion (Fe

Indexed as

AromataseOxidation-ReductionAndrostenedioneAnimalsAnionsCytochrome P450 Family 2Ferric CompoundsHumansPeroxidesRabbitsSteroidsAndrostenedioneAnionsAromataseCYP19A1 protein, humanCytochrome P450 Family 2Ferric CompoundsPeroxidesSteroidscytochrome P450enzyme mechanismsmass spectrometryoxidation mechanismssteroid biosynthesis

Identifiers

PMID38820076
PMCPMC11519728

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.