Evidence map›Paper›PMID 38820035›Full record

ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2024

Circulating long noncoding RNA, Zfpm2-As1, and XIST based on medical data analysis are potential plasma biomarkers for gastric cancer diagnosis.

Han Liang, Hao Li, Nan Xia, Jingjing Chen, Linlin Gao, Hao Liu, Ping Lyu, Xiaolin Guo, Ziwei Yang

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Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Han LiangClinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Hao LiClinical Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Nan XiaClinical Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Jingjing ChenClinical Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Linlin GaoClinical Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Hao LiuClinical Laboratory, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Ping LyuClinical Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Xiaolin GuoClinical Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Ziwei YangClinical Laboratory, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong noncoding RNAs (lncRNAs) participate in diseases, especially tumorigenesis, including gastric cancer (GC). Although lncRNAs in GC tissues have been extensively studied in previous research, the possible significance of circulating lncRNAs in diagnosing GC is still unknown.

objectiveThe present work investigated lncRNAs ZFPM2-AS1 and XIST with high expression in GC tissues proved as potential plasma biomarkers from 20 early GC cases, 100 GC cases, and 90 normal subjects.

methodsThe possible correlation between ZFPM2-AS1 and XIST expression levels was analyzed with general characteristics and clinicopathological features. The performance in diagnosis was assessed according to receiver operating characteristic (ROC) analysis.

resultsAccording to the results, XIST and ZFPM2-AS1 expression remarkably increased within GC plasma relative to normal subjects (P< 0.01); besides, lncRNA XIST expression after surgery had a tendency of downregulation compared with preoperative levels (P< 0.05). Moreover, the area under ROC curve (AUC) values were 0.62 for ZFPM2-AS1 and 0.68 for XIST, while the pooled AUC value of CA-724 and two lncRNAs was 0.751.

conclusionCirculating lncRNAs ZFPM2-AS1 and XIST can serve as the candidate plasma biomarkers used to diagnose GC.

Indexed as

Biomarkers, TumorRNA, Long NoncodingStomach NeoplasmsAdultAgedDNA-Binding ProteinsFemaleHumansMaleMiddle AgedROC CurveBiomarkers, TumorDNA-Binding ProteinsRNA, Long NoncodingXIST non-coding RNAbiomarkerdiagnosisgastric cancerLong noncoding RNAplasmaXISTZFPM2-AS1

Identifiers

PMID38820035
PMCPMC11612959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.