Evidence map›Paper›PMID 38820016›Full record

ArticleJournal of Alzheimer's disease : JAD2024

Amyloid-β Deposition Predicts Grocery Shopping Performance in Older Adults Without Cognitive Impairment.

Lisa A Zukowski, Sarah A Brinkerhoff, Ilana Levin, Troy M Herter, Lena Hetrick, Samuel N Lockhart, Michael E Miller, Paul J Laurienti, Stephen B Kritchevsky, Christina E Hugenschmidt

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa A ZukowskiDepartment of Physical Therapy, High Point University, High Point, NC, USA.
Sarah A BrinkerhoffDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Ilana LevinDepartment of Physical Therapy, High Point University, High Point, NC, USA.
Troy M HerterDepartment of Exercise Science, University of South Carolina, Columbia, SC, USA.
Lena HetrickDepartment of Neuroscience, High Point University, High Point, NC, USA.
Samuel N LockhartSticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Michael E MillerDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Paul J LaurientiDepartment of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Stephen B KritchevskySticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Christina E HugenschmidtSticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Combining assessment of cognition, eye movement, and gait in naturalistic settings to differentiate subclinical Alzheimer's pathology.R01AG052419 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KRITCHEVSKY, STEPHEN B., LAURIENTI, PAUL · 2017 to 2022
$4.2M
NCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG052419
6 · The paper itself

Abstract

Background: A screening tool sensitive to Alzheimer's disease (AD) risk factors, such as amyloid-β (Aβ) deposition, and subtle cognitive changes, best elicited by complex everyday tasks, is needed. Objective: To determine if grocery shopping performance could differentiate older adults at elevated risk of developing AD (OAer), older adults at low risk of developing AD (OAlr), and young adults (YA), and if amount of Aβ deposition could predict grocery shopping performance in older adults (OA). Methods: Twenty-one OAer (78±5 years), 33 OAlr (78±5 years), and 28 YA (31±3 years) performed four grocery shopping trials, with the best and worst performances analyzed. Measures included trial time, number of correct items, number of grocery note fixations, and number of fixations and percentage of time fixating on the correct shelving unit, correct brand, and correct shelf. Linear mixed effects models compared measures by performance rank (best, worst) and group (OAer, OAlr, YA), and estimated the effect of Aβ deposition on measures in OA. Results: Relative to their best performance, OAer and OAlr exhibited more correct shelving unit fixations and correct brand fixations during their worst performance, while YA did not. Within OA's worst performance, greater Aβ deposition was associated with a smaller percentage of time fixating on the correct shelving unit, correct shelf, and correct brand. Within OA, greater Aβ deposition was associated with more grocery note fixations. Conclusions: OA with elevated Aβ deposition may exhibit subtle working memory impairments and less efficient visual search strategies while performing a cognitively demanding everyday task.

Indexed as

Amyloid beta-PeptidesActivities of Daily LivingAdultAgedAged, 80 and overAgingAlzheimer DiseaseBrainFemaleHumansMaleNeuropsychological TestsPositron-Emission TomographyAmyloid beta-PeptidesAlzheimer’s diseasecognitioneye-trackingvisual processing

Identifiers

PMID38820016
PMCPMC12184689

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.