Evidence map›Paper›PMID 38819756›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2024

Antibiotics-Induced Intestinal Immunomodulation Attenuates Experimental Autoimmune Neuritis (EAN).

Alina Sprenger-Svačina, Ines Klein, Martin K R Svačina, Ilja Bobylev, Felix Kohle, Christian Schneider, Finja Schweitzer, Nadin Piekarek, Mohammed Barham, Maria J G T Vehreschild and 2 more

Abstract read
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In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alina Sprenger-SvačinaDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany. alina.sprenger-svacina@uk-koeln.de.
Ines KleinDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Martin K R SvačinaDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Ilja BobylevDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Felix KohleDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Christian SchneiderDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Finja SchweitzerDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Nadin PiekarekExperimental Medicine, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.
Mohammed BarhamDepartment II of Anatomy, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Maria J G T VehreschildDepartment I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.
Helmar C LehmannDepartment of Neurology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Fedja FarowskiDepartment I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe composition of gut microbiota plays a pivotal role in priming the immune system and thus impacts autoimmune diseases. Data on the effects of gut bacteria eradication via systemic antibiotics on immune neuropathies are currently lacking. This study therefore assessed the effects of antibiotics-induced gut microbiota alterations on the severity of experimental autoimmune neuritis (EAN), a rat model of Guillain-Barré Syndrome (GBS). Myelin P0 peptide 180-199 (P0 180-199)-induced EAN severity was compared between adult Lewis rats (12 weeks old) that received drinking water with or without antibiotics (colistin, metronidazole, vancomycin) and healthy rats, beginning antibiotics treatment immediately after immunization (day 0), and continuing treatment for 14 consecutive days. Neuropathy severity was assessed via a modified clinical score, and then related to gut microbiota alterations observed after fecal 16S rRNA gene sequencing at baseline and after EAN induction. Effectors of gut mucosal and endoneurial immunity were assessed via immunostaining. EAN rats showed increased gut mucosal permeability alongside increased mucosal CD8

Indexed as

Anti-Bacterial AgentsGastrointestinal MicrobiomeImmunomodulationNeuritis, Autoimmune, ExperimentalRats, Inbred LewAnimalsMaleRatsAnti-Bacterial AgentsAutoimmunityGuillain-Barré Syndrome (GBS)Gut microbiotaImmune neuropathiesIntestinal barrier

Identifiers

PMID38819756
PMCPMC11143056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.