Evidence map›Paper›PMID 38819322›Full record

ArticleThe Journal of infectious diseases2024

Impact of Variable Sampling on Estimates of HIV-1 Reservoir Formation Dates.

Edward N Kankaka, Art F Y Poon, Thomas C Quinn, Larry W Chang, Jessica L Prodger, Andrew D Redd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Edward N KankakaRakai Health Sciences Program, Kalisizo, Uganda.
Art F Y PoonDepartment of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.
Thomas C QuinnDivision of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA.
Larry W ChangDivision of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA.
Jessica L ProdgerDepartment of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Andrew D ReddDivision of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4651-1423

Funding

REACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Multidisciplinary Research Training to Understand and Reduce HIV Incidence in UgandaD43TW010557 · FIC · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2018 to 2022
$1.6M
amfAR, The Foundation for AIDS Research 109844Canada Foundation for InnovationCIHR PJT-155990FIC NIH HHS D43 TW010557FIC NIH HHS D43TW010557Government of CanadaMinistry of Colleges and UniversitiesNational Institute of Allergy and Infectious DiseasesNHLBI NIH HHSNIAID NIH HHS UM1 AI164565NIH HHS UM1 AI164565
6 · The paper itself

Abstract

Timing of human immunodeficiency virus-1 (HIV-1) reservoir formation is important for informing HIV cure efforts. It is unclear how much of the variability seen in dating reservoir formation is due to sampling and gene-specific differences. We used a Bayesian extension of root to tip regression (bayroot) to reestimate formation date distributions in participants from Swedish and South African cohorts, and assessed the impact of variable timing, frequency, and depth of sampling on these estimates. Significant shifts in formation date distributions were only observed with use of faster-evolving genes, while timing, frequency, and depth of sampling had minor or no significant effect on estimates.

Indexed as

Bayes TheoremHIV-1HIV InfectionsAdultCohort StudiesFemaleHumansMaleSouth AfricaSwedenTime FactorsVirus LatencybayrootHIVHIV curereservoir datingviral reservoir

Identifiers

PMID38819322
PMCPMC11481468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.