Evidence map›Paper›PMID 38819232›Full record

ArticleAging2024

LASSO regression and WGCNA-based telomerase-associated lncRNA signaling predicts clear cell renal cell carcinoma prognosis and immunotherapy response.

Cheng Shen, Kaiyao Jiang, Wei Zhang, Baohui Su, Zhenyu Wang, Xinfeng Chen, Bing Zheng, Tao He

Abstract read
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cheng ShenDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Kaiyao JiangDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Wei ZhangDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Baohui SuDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Zhenyu WangDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Xinfeng ChenDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Bing ZhengDepartment of Urology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
Tao HeParty Committe and Hospital Administration Office, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether telomerase-associated lncRNA expression affects the prognosis and anti-tumor immunity of patients with renal clear cell carcinoma (ccRCC).

methodsA series of analyses were performed to establish a prognostic risk model and validate its accuracy. Immune-related analyses were performed to assess further the association between immune status, tumor microenvironment, and prognostic risk models.

resultsEight telomerase-associated lncRNAs associated with prognosis were identified and applied to establish a prognostic risk model. Overall survival was higher in the low-risk group.

conclusionThe established prognostic risk model has a good predictive ability for the prognosis of ccRCC patients and provides a new possible therapeutic target for ccRCC.

Indexed as

Carcinoma, Renal CellImmunotherapyKidney NeoplasmsRNA, Long NoncodingTelomeraseBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMalePrognosisSignal TransductionTumor MicroenvironmentBiomarkers, TumorRNA, Long NoncodingTelomeraseimmune infiltrationrenal clear cell carcinomasignaturetelomerase genes (TRs)

Identifiers

PMID38819232
PMCPMC11210217

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.