Evidence map›Paper›PMID 38819027›Full record

ArticleIntegrative cancer therapies

In-vitro Cytotoxicity Investigations for Phytoconstituents of Saudi Medicinal Plants With Putative Ocular Effects.

Ali Hendi Alghamdi, Aimun A E Ahmed, Haidar Abdalgadir, Mahadi Bashir, Asaad Khalid, Ashraf N Abdalla, Mohamed E Elzubier, Riyad Adnan Almaimani, Bassem Refaat, Khalid Alzahrani and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Molecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ali Hendi AlghamdiAl Baha University, Al Baha, Saudi Arabia.ORCID 0000-0003-4451-3820
Aimun A E AhmedAl Baha University, Al Baha, Saudi Arabia.
Haidar AbdalgadirAl Baha University, Al Baha, Saudi Arabia.
Mahadi BashirAl Baha University, Al Baha, Saudi Arabia.
Asaad KhalidJazan University, Jazan, Saudi Arabia.
Ashraf N AbdallaUmm Al-Qura University, Makkah, Saudi Arabia.
Mohamed E ElzubierUmm Al-Qura University, Makkah, Saudi Arabia.
Riyad Adnan AlmaimaniUmm Al-Qura University, Makkah, Saudi Arabia.
Bassem RefaatUmm Al-Qura University, Makkah, Saudi Arabia.
Khalid AlzahraniAl Baha University, Al Baha, Saudi Arabia.
Saleh M S AlghamdiAl Baha University, Al Baha, Saudi Arabia.
Sheraz GulFraunhofer Institute for Translational Medicine and Pharmacology, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetastatic secondary ocular tumors spread from systemic malignancies, including breast cancer. This study aimed to evaluate the cytotoxicity of extracts from 5 medicinal plants native to Saudi Arabia.

methodsFor preliminary activity screening, cytotoxicity using the MTT assay and selectivity index determinations were made for medicinal plant extracts against various cancer cell-lines. The most promising extract was subjected to GC-MS analysis to determine the phytochemical composition. Clonogenic assays were performed using the most promising extract to confirm the initial results. Finally, western blot analysis was used to determine the modulation in expression of survivin and P27 suppressor genes in the human breast adenocarcinoma (MCF7) cell-line to understand the potential mechanistic properties of the active plant extract.

resultsThe 5 plant extracts showed various cytotoxic activity levels using IC

conclusionLeaves of

Indexed as

Plant ExtractsPlants, MedicinalAntineoplastic Agents, PhytogenicBreast NeoplasmsCell Line, TumorFemaleGas Chromatography-Mass SpectrometryHumansMCF-7 CellsPhytochemicalsSaudi ArabiaSurvivinAntineoplastic Agents, PhytogenicBIRC5 protein, humanPhytochemicalsPlant ExtractsSurvivinapoptosisCapparis spinosa Lcell cycleclonogenicitycytotoxicityMTT assay

Identifiers

PMID38819027
PMCPMC11143859

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.