Evidence map›Paper›PMID 38818960›Full record

ArticleBJS open2024

Lymphatic spread patterns in young versus elderly patients with stage III colon cancer.

Jihyung Song, Kozo Kataoka, Manabu Inoue, Takeshi Yamada, Manabu Shiozawa, Naohito Beppu, Sho Kuriyama, Takeshi Suto, Nobuhisa Matsuhashi, Yusuke Sakura and 5 more

Abstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BJS open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jihyung SongDivision of Lower GI, Department of Gastroenterological Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.
Kozo KataokaDivision of Lower GI, Department of Gastroenterological Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.ORCID 0000-0003-2043-8184
Manabu InoueDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Takeshi YamadaDepartment of Gastrointestinal and Hepato-Billiary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.ORCID 0000-0002-1436-7482
Manabu ShiozawaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Naohito BeppuDivision of Lower GI, Department of Gastroenterological Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.
Sho KuriyamaDepartment of Gastrointestinal and Hepato-Billiary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Takeshi SutoDepartment of Gastroenterological Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Nobuhisa MatsuhashiDepartment of Gastroenterological Surgery/Pediatric Surgery, Gifu University, Gifu, Japan.
Yusuke SakuraDepartment of Gastrointestinal Surgery, Shimane Prefectural Central Hospital, Izumo, Japan.
Akiyoshi KanazawaDepartment of Gastrointestinal Surgery, Shimane Prefectural Central Hospital, Izumo, Japan.
Hiroyasu KagawaDivision of Colon and Rectal Surgery, Shizuoka Cancer Center, Shunto-gun, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0002-3366-3826
Wim CeelenDepartment of GI Surgery, Ghent University Hospital, and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium.ORCID 0000-0001-7692-4419
Masataka IkedaDivision of Lower GI, Department of Gastroenterological Surgery, School of Medicine, Hyogo Medical University, Nishinomiya, Japan.

Funding

JSPS KAKENHI 21K15494
6 · The paper itself

Abstract

backgroundThe anatomical pattern of lymph nodes spread differs between young (aged 45 years or younger) and elderly (aged 80 years or older) patients with stage III colon cancer and is poorly investigated.

methodsTwo groups of patients (young and elderly) with stage III colon cancer who underwent upfront extensive (D3) lymphadenectomy at eight Japanese centres between 1998 and 2018 were retrospectively analysed. The primary endpoint was the proportion of positive central lymph nodes. The lymph nodes spreading pattern and its prognostic impact on recurrence-free survival and overall survival in the two groups were also compared.

resultsTwo hundred and ten young patients and 348 elderly patients were identified and compared. The total number of lymph nodes harvested and the total number of invaded lymph nodes were significantly higher in younger patients compared with elderly patients (median of 31.5 (3-151) versus 21 (3-116), P < 0.001 and median of 3 (1-21) versus 2 (1-25), P < 0.001 respectively). The proportion of positive central lymph nodes were higher in younger patients than in elderly patients (9.52% (95% c.i. 6.24 to 14.2%) versus 4.59% (95% c.i. 2.84 to 7.31%), P = 0.012). In multivariate models for recurrence-free survival, central lymph nodes invasion were identified as a poor prognostic factor in younger patients (HR 5.21 (95% c.i. 1.76 to 15.39)) but not in elderly patients (HR 1.73 (95% c.i. 0.80 to 3.76)).

conclusionYoung patients with stage III colon cancer have a higher risk of central lymph nodes invasion, suggesting a more aggressive disease biology. The presence of central lymph nodes invasion are associated with a worse outcome in young patients.

Indexed as

Colonic NeoplasmsLymphatic MetastasisLymph Node ExcisionLymph NodesNeoplasm StagingAdultAgedAged, 80 and overAge FactorsDisease-Free SurvivalFemaleHumansJapanMaleMiddle AgedPrognosis

Identifiers

PMID38818960
PMCPMC11140818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.