Evidence map›Paper›PMID 38818718›Full record

Trial reportThe British journal of nutrition2024

Evaluating mineral biomarkers as mediators and moderators of behavioural improvements in a randomised controlled trial of multinutrients for children with attention-deficit/hyperactivity disorder.

Lisa M Robinette, Jeanette M Johnstone, Priya Srikanth, Alisha M Bruton, Martina Ralle, Hayleigh K Ast, Ryan D Bradley, Brenda Leung, L Eugene Arnold, Irene E Hatsu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa M Robinette *Department of Human Sciences, The Ohio State University, Columbus, OH, USA.ORCID 0000-0002-9314-9538
Jeanette M Johnstone *Center for Mental Health Innovation, Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
Priya SrikanthOregon Health & Science University, Portland, OR, USA.
Alisha M BrutonCenter for Mental Health Innovation, Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
Martina RalleDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Hayleigh K AstCenter for Mental Health Innovation, Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
Ryan D BradleyNational University of Natural Medicine, Helfgott Research Institute, Portland, OR, USA.
Brenda LeungFaculty of Health Sciences, University of Lethbridge, Lethbridge, AB, Canada.
L Eugene ArnoldDepartment of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH, USA.
Irene E HatsuDepartment of Human Sciences, The Ohio State University, Columbus, OH, USA.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
CAM Research Training in Neuroscience &StressT32AT002688 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI OKEN, BARRY S, SOUMYANATH, AMALA · 2005 to 2025
$7.2M
Building Research across Interdisciplinary Gaps (BRIDG) R90 Training Program - Administrative SupplementR90AT008924 · NCCIH · NATIONAL UNIVERSITY OF NATURAL MEDICINE · PI BRADLEY, RYAN D, ZWICKEY, HEATHER LEA · 2015 to 2025
$5.2M
Optimizing Research Methodology in a Multinutrient Study of Racially and Ethnically Diverse Children with ADHD and Emotional DysregulationK23AT012068 · NCCIH · OREGON HEALTH & SCIENCE UNIVERSITY · PI JOHNSTONE, JEANETTE M · 2022 to 2025
$700k
ICP-MS to Measure Elemental ConcentrationsS10RR025512 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI RALLE, MARTINA · 2009 to 2009
$168k
NCATS NIH HHS UL1 TR002369NCATS NIH HHS UL1 TR002733NCCIH NIH HHS K23 AT012068NCCIH NIH HHS R90 AT008924NCCIH NIH HHS T32 AT002688NCRR NIH HHS S10 RR025512
6 · The paper itself

Abstract

Essential minerals are cofactors for synthesis of neurotransmitters supporting cognition and mood. An 8-week fully-blind randomised controlled trial of multinutrients for attention-deficit/hyperactivity disorder (ADHD) demonstrated three times as many children (age 6-12) had significantly improved behaviour ('treatment responders') on multinutrients (54 %) compared with placebo (18 %). The aim of this secondary study was to evaluate changes in fasted plasma and urinary mineral concentrations following the intervention and their role as mediators and moderators of treatment response. Fourteen essential or trace minerals were measured in plasma and/or urine at baseline and week eight from eighty-six participants (forty-nine multinutrients, thirty-seven placebos). Two-sample

Indexed as

Attention Deficit Disorder with HyperactivityBiomarkersMineralsChildDietary SupplementsFemaleHumansMaleTrace ElementsTreatment OutcomeBiomarkersMineralsTrace ElementsAttention-deficit/hyperactivity disorderChildrenEmotional dysregulationMediationMineralsModerationNutrientsSupplement

Identifiers

PMID38818718
PMCPMC11473203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.