ReviewJournal of tissue engineering
Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics.
Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- pH-responsive injectable hydrogel dressing integrating antibacteria, antioxidation, anti-inflammation, and angiogenesis for infected wound healing.International journal of pharmaceutics: X · 2026Article
- Sesamin Promotes Diabetic Wound Healing by Inhibiting Ferroptosis via the SIRT1/Keap1/Nrf2 Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Programming the Diabetic-Infected Wound Microenvironment With a Smart Hydrogel for Ordered Healing Cascade Restoration.Advanced healthcare materials · 2026Article
- Regenerative Microbiology: Harnessing Bacterial Antagonism and Spatiotemporal Signaling for Diabetic Wound Repair.Smart medicine · 2026Review
- Multifunctional Manganese Oxide Nanocomposite Hydrogel With Synergistic Reactive Oxygen Species-Scavenging, Oxygen-Generating, Immunomodulatory, and Photothermal Antimicrobial Activities for Enhanced Diabetic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Structure-Function Engineering of Hydrogel-MOF Polymer Composites for Regenerative Wound Dressings with Emerging Antiviral Biointerface Functions.Gels (Basel, Switzerland) · 2026Review
- Review
- Glucose-responsive "sense-and-treat" microneedle patch for promoting diabetic chronic wound healing.Materials today. Bio · 2026Article
- Multidimensional nano-ion composite hydrogel based on enzymatic blood glucose control, gas therapy and ion liquid permeation for repairing diabetic wounds.Materials today. Bio · 2026Article
- Chondroitin Sulfate-Based MPDA@MnOPolymers · 2026Article
- Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration.Nature communications · 2026Article
- Cellulose-Based Hydrogels for Chronic Wound Healing: Bridging Biomaterial Design and Clinical Unmet Needs.Gels (Basel, Switzerland) · 2026Review
- pH/glucose dual-responsive drug release hydrogel loaded with tannic acid and gallium ions enhances diabetic wound healing upon bacterial infection.Journal of biological engineering · 2026Article
- NbAdvanced healthcare materials · 2026Article
- Sustained-release CGRP microspheres accelerate diabetic wound healing by synergistically promoting neurovascular regeneration through modulation of macrophage and endothelial cell functions.Materials today. Bio · 2026Article
- Bioprinting in Tissue Repair and Its ENT Applications.Polymers · 2026Review
- Galectins: Role and Therapeutics in Diabetes and Diabetic Foot Ulcers.Biomolecules · 2026Review
- Biomaterial-mediated remodelling of the inflammatory microenvironment: a pH/ROS-responsive EGCG-metformin hydrogel for infected diabetic wound regeneration.Frontiers in cell and developmental biology · 2026Article
- Review
- A self-oxygenating polyphenol-nanozyme hydrogel remodels the inflammatory microenvironment for diabetic wound healing.Regenerative biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds and their potential to induce disability. The intricate healing mechanisms of diabetic wounds are multifaceted, influenced by ambient microenvironment, including prolonged hyperglycemia, severe infection, inflammation, elevated levels of reactive oxygen species (ROS), ischemia, impaired vascularization, and altered wound physicochemical properties. In recent years, hydrogels have emerged as promising candidates for diabetic wound treatment owing to their exceptional biocompatibility and resemblance to the extracellular matrix (ECM) through a three-dimensional (3D) porous network. This review will first summarize the microenvironment alterations occurring in the diabetic wounds, aiming to provide a comprehensive understanding of its pathogenesis, then a comprehensive classification of recently developed hydrogels will be presented, encompassing properties such as hypoglycemic effects, anti-inflammatory capabilities, antibacterial attributes, ROS scavenging abilities, promotion of angiogenesis, pH responsiveness, and more. The primary objective is to offer a valuable reference for repairing diabetic wounds based on their unique microenvironment. Moreover, this paper outlines potential avenues for future advancements in hydrogel dressings to facilitate and expedite the healing process of diabetic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.