ArticleBrain communications2024
Contribution of new and chronic cortical lesions to disability accrual in multiple sclerosis.
Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Cortical lesions in multiple sclerosis: 25 years of progress, remaining challenges and future directions.Nature reviews. Neurology · 2026Review
- Quantifying cortical lesions in multiple sclerosis MRI datasets using multi-contrast post-processing and deep learning.Communications medicine · 2026Article
- Cortical Lesions Form Predominantly in Early Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2026Article
- Subcortical microglial inflammation is uniquely linked to subpial cortical demyelination in multiple sclerosis.NeuroImage. Clinical · 2026Article
- Spinal cord versus brain imaging biomarkers of multiple sclerosis trajectory combining 7T and 3T MRI.Brain communications · 2026Article
- A comparative study of deep learning for cortical lesion MRI segmentation with explainability analysis in multiple sclerosis.NeuroImage. Clinical · 2026Article
- Benchmarking and Explaining Deep Learning Cortical Lesion MRI Segmentation in Multiple Sclerosis.ArXiv · 2025Article
- Evolution of Cortical Lesions and Function-Specific Cognitive Decline in People With Multiple Sclerosis.Neurology · 2025Article
- Explaining Uncertainty in Multiple Sclerosis Lesion Segmentation Beyond Prediction Errors.ArXiv · 2025Article
- Towards a biological view of multiple sclerosis from early subtle to clinical progression: an expert opinion.Journal of neurology · 2025Review
- BrainAgeNeXt: Advancing brain age modeling for individuals with multiple sclerosis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Multiple sclerosis: 2024 update.Free neuropathology · 2025Review
- Neuroimaging phenotype characterization of early aggressive and late severe multiple sclerosis: a case-control study.Brain communications · 2025Article
- The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.Brain communications · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
Abstract
Cortical lesions are common in multiple sclerosis and are associated with disability and progressive disease. We asked whether cortical lesions continue to form in people with stable white matter lesions and whether the association of cortical lesions with worsening disability relates to pre-existing or new cortical lesions. Fifty adults with multiple sclerosis and no new white matter lesions in the year prior to enrolment (33 relapsing-remitting and 17 progressive) and a comparison group of nine adults who had formed at least one new white matter lesion in the year prior to enrolment (active relapsing-remitting) were evaluated annually with 7 tesla (T) brain MRI and 3T brain and spine MRI for 2 years, with clinical assessments for 3 years. Cortical lesions and paramagnetic rim lesions were identified on 7T images. Seven total cortical lesions formed in 3/30 individuals in the stable relapsing-remitting group (median 0, range 0-5), four total cortical lesions formed in 4/17 individuals in the progressive group (median 0, range 0-1), and 16 cortical lesions formed in 5/9 individuals in the active relapsing-remitting group (median 1, range 0-10, stable relapsing-remitting versus progressive versus active relapsing-remitting
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Registered trials
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