ReviewBioengineering & translational medicine2024
Growth factors and growth factor gene therapies for treating chronic wounds.
Review in Bioengineering & translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potential of the Nano-Encapsulation of Antioxidant Molecules in Wound Healing Applications: An Innovative Strategy to Enhance the Bio-Profile.Molecules (Basel, Switzerland) · 2025Pooled it
- Zinc silicate microspheres-mediated bacterial metabolic interference and microenvironment remodeling for chronic wound repair.Bioactive materials · 2027Article
- Lysophosphatidic acid promotes cutaneous wound healing through vascular maturation and fibroblast activation in a murine model.Inflammation and regeneration · 2026Article
- Smart Polymeric Wound Dressings for Wound Treatment: Contributions and Applications.International journal of molecular sciences · 2026Review
- Regenerative Microbiology: Harnessing Bacterial Antagonism and Spatiotemporal Signaling for Diabetic Wound Repair.Smart medicine · 2026Review
- Targeting Biofilms in Chronic Wounds: Emerging Strategies with Antimicrobial Nanocomposites.Journal of functional biomaterials · 2026Review
- Innovative applications of multidimensional engineered hydrogels in wound healing.Journal of advanced research · 2026Review
- Advances in diabetic wound healing: from pathophysiology to emerging therapies.Acta diabetologica · 2026Review
- Electronic Skins for Advanced Wound Healing: Biomimetic Thermoregulation and Bioelectrically Active Systems.Polymers · 2026Review
- Article
- Deciphering skin architecture, wound pathophysiology and molecular mechanisms of healing: insights into immune response and therapeutic strategies.Frontiers in bioengineering and biotechnology · 2026Review
- Identification of Novel Growth Factor Conjugated Nanofibers for Stimulation of Neuronal Growth.Macromolecular bioscience · 2026Article
- Exploring New Horizons in Wound Healing: A Comprehensive Analysis.Recent advances in inflammation & allergy drug discovery · 2026Review
- Platelet-Rich Plasma (PRP) and Recombinant Growth Factor Therapies in Cutaneous Wound Healing: Mechanisms, Clinical Applications, and Future Directions.Journal of clinical medicine · 2025Review
- Co-Delivery of Ca-MOF and Mg-MOF Using Nanoengineered Hydrogels to Promote In Situ Mineralization and Bone Defect Repair: In Vitro and In Vivo Analysis.Advanced healthcare materials · 2025Article
- Scaffold-free cell sheet therapies: clinical advances, global approval landscapes, and strategic directions to address regenerative medicine barriers.Stem cell research & therapy · 2025Review
- Heparin-Based Growth Factor Delivery Platforms: A Review.Pharmaceutics · 2025Review
- Biological Macromolecule-Based Dressings for Combat Wounds: From Collagen to Growth Factors-A Review.Medical sciences (Basel, Switzerland) · 2025Review
- Gene Therapies in Dermatological Diseases: A Breakthrough in Treatment.International journal of molecular sciences · 2025Review
- Towards Intelligent Wound Care: Hydrogel-Based Wearable Monitoring and Therapeutic Platforms.Polymers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Chronic wounds are an unmet clinical need affecting millions of patients globally, and current standards of care fail to consistently promote complete wound closure and prevent recurrence. Disruptions in growth factor signaling, a hallmark of chronic wounds, have led researchers to pursue growth factor therapies as potential supplements to standards of care. Initial studies delivering growth factors in protein form showed promise, with a few formulations reaching clinical trials and one obtaining clinical approval. However, protein-form growth factors are limited by instability and off-target effects. Gene therapy offers an alternative approach to deliver growth factors to the chronic wound environment, but safety concerns surrounding gene therapy as well as efficacy challenges in the gene delivery process have prevented clinical translation. Current growth factor delivery and gene therapy approaches have primarily used single growth factor formulations, but recent efforts have aimed to develop multi-growth factor approaches that are better suited to address growth factor insufficiencies in the chronic wound environment, and these strategies have demonstrated improved efficacy in preclinical studies. This review provides an overview of chronic wound healing, emphasizing the need and potential for growth factor therapies. It includes a summary of current standards of care, recent advances in growth factor, cell-based, and gene therapy approaches, and future perspectives for multi-growth factor therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.