Evidence map›Paper›PMID 38818084›Full record

ArticleGlobal medicine and therapeutics2024

Comparison of LIRADS 5 Image Guided Core Biopsy Derived From Formalin Fixed and Frozen Tissue Cores for Radiogenomics and Radioproteomics Analysis in Well, Moderate and Poorly Differentiated Hepatocellular Carcinoma.

Margaret Simonian, David S K Lu, Julian Whitelegge, Whitaker Cohn, Preeti Ahuja, William Hsu, Steven S Raman

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Global medicine and therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Margaret SimonianDept of Radiological Sciences, David Geffen School of Medicine, UCLA, USA.
David S K LuDept of Radiological Sciences, David Geffen School of Medicine, UCLA, USA.
Julian WhiteleggeSemel Institute for Neuroscience & Human Behavior, Pasarow mass spectrometry lab, David Geffen School of Medicine, UCLA, USA.
Whitaker CohnSemel Institute for Neuroscience & Human Behavior, Pasarow mass spectrometry lab, David Geffen School of Medicine, UCLA, USA.
Preeti AhujaDept of Radiological Sciences, David Geffen School of Medicine, UCLA, USA.
William HsuDept of Radiological Sciences, David Geffen School of Medicine, UCLA, USA.
Steven S RamanDept of Radiological Sciences, David Geffen School of Medicine, UCLA, USA.

Funding

New Technologies for Real-Time MRI-Guided Robotic-Assisted Abdominal InterventionsR01EB031934 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LU, DAVID S, TSAO, TSU-CHIN TC · 2022 to 2025
$2.5M
Organ-specific NRF2-mediated protein signatures of radiation exposure & tissue daR01AI101888 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WHITELEGGE, JULIAN P · 2012 to 2016
$1.9M
NIAID NIH HHS R01 AI101888NIBIB NIH HHS R01 EB031934
6 · The paper itself

Abstract

The aim of this pilot study is to evaluate and compare the quality of the genomics and proteomics data obtained from paired Formalin Fixed Paraffin Embedded (FFPE) and frozen (FF) tissue percutaneous core biopsies of Liver Imaging Reporting and Data System 5 (LIRADS 5) hepatocellular carcinoma (HCC) of varying histological grades. The preliminary data identified differentially expressed proteins and genes in poor, moderate and well differentiated HCC biopsies, with a greater efficacy in fresh frozen samples. The data offered valuable insights into the characteristics and suitability of samples for future studies.

Indexed as

biomarkersLiver HCCradiogenomicsradioproteomics

Identifiers

PMID38818084
PMCPMC11138132

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.