ArticlemLife2022
Fatty acid feedstocks enable a highly efficient glyoxylate-TCA cycle for high-yield production of β-alanine.
Article in mLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Recent Advances in Beta-Alanine Production via Enzymatic Catalysis and Microbial Whole-Cell Catalysis.Biology · 2026Review
- Recent advances in nonprotein amino acids: insights from function to biosynthesis.Journal of animal science and biotechnology · 2026Review
- Synergistic Production of Lycopene and β-Alanine Through Engineered Redox Balancing inInternational journal of molecular sciences · 2025Article
- Metabolic Profiling in Plasma and Brain Induced by 17β-Estradiol Supplementation in Ovariectomized Mice.ACS omega · 2024Article
- Advances in the synthesis of β-alanine.Frontiers in bioengineering and biotechnology · 2023Review
- Fatty acid feedstocks enable a highly efficient glyoxylate-TCA cycle for high-yield production of β-alanine.mLife · 2022Article
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Authors and funding
6 authors.
Funding
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Abstract
Metabolic engineering to produce tricarboxylic acid (TCA) cycle-derived chemicals is usually associated with problems of low production yield and impaired cellular metabolism. In this work, we found that fatty acid (FA) feedstocks could enable high-yield production of TCA cycle-derived chemicals, while maintaining an efficient and balanced metabolic flux of the glyoxylate-TCA cycle, which is favorable for both product synthesis and cell growth. Here, we designed a novel synthetic pathway for production of β-alanine, an important TCA cycle-derived product, from FAs with a high theortecial yield of 1.391 g/g. By introducing
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