Evidence map›Paper›PMID 38817635›Full record

ArticleJournal of the Endocrine Society2024

Soluble CD14 and Incident Diabetes Risk: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

Kaileen Cruden, Katherine Wilkinson, Debora Kamin Mukaz, Timothy B Plante, Neil A Zakai, D Leann Long, Mary Cushman, Nels C Olson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaileen CrudenLarner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.
Katherine WilkinsonDepartment of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.
Debora Kamin MukazDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.ORCID https://orcid.org/0000-0001-5573-2573
Timothy B PlanteDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.ORCID https://orcid.org/0000-0001-9992-9597
Neil A ZakaiDepartment of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.ORCID https://orcid.org/0000-0001-8824-4410
D Leann LongDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID https://orcid.org/0000-0001-8614-7190
Mary CushmanDepartment of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.ORCID https://orcid.org/0000-0002-7871-6143
Nels C OlsonDepartment of Pathology and Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.ORCID https://orcid.org/0000-0003-1192-9969

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kathryn H Morelli · 2020 to 2026
$17.4M
NIGMS NIH HHS P20 GM135007
6 · The paper itself

Abstract

Context: Soluble CD14 (sCD14) is an inflammation biomarker with higher concentrations in White than Black adults. Higher sCD14 is seen in insulin resistance and diabetes. There are limited data on the relationship between sCD14 and incident diabetes. Objective: To determine the association of sCD14 with incident diabetes risk in a large biracial US cohort and evaluate whether relationships differ by race. Design: This study included 3401 Black and White participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study without baseline diabetes who completed baseline and follow-up in-home visits. Modified Poisson regression models estimated risk ratios (RR) of incident diabetes per 1-SD increment sCD14, with adjustment for risk factors. A sCD14-by-race interaction evaluated whether associations differed by race. Results: There were 460 cases of incident diabetes over a mean 9.5 years of follow-up. The association of sCD14 with diabetes differed by race ( Conclusion: sCD14 was associated with incident diabetes risk in White but not Black adults, but this association was explained by diabetes risk factors.

Indexed as

biomarkersdiabetesinflammationracial groups

Identifiers

PMID38817635
PMCPMC11137750

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.