Evidence map›Paper›PMID 38817587›Full record

ArticleChemical science2024

Structural elucidation of HIV-1 G-quadruplexes in a cellular environment and their ligand binding using responsive

Sarupa Roy, Priyasha Majee, Sruthi Sudhakar, Satyajit Mishra, Jeet Kalia, P I Pradeepkumar, Seergazhi G Srivatsan

Abstract read
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarupa RoyDepartment of Chemistry, Indian Institute of Science Education and Research (IISER), Pune Dr Homi Bhabha Road Pune 411008 India srivatsan@iiserpune.ac.in.
Priyasha MajeeDepartment of Chemistry, Indian Institute of Technology Bombay Mumbai 400076 India pradeep@chem.iitb.ac.in.
Sruthi SudhakarDepartment of Chemistry, Indian Institute of Technology Bombay Mumbai 400076 India pradeep@chem.iitb.ac.in.
Satyajit MishraDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal Bhopal Bypass Road, Bhauri Bhopal 462066 India.
Jeet KaliaDepartment of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal Bhopal Bypass Road, Bhauri Bhopal 462066 India.ORCID https://orcid.org/0000-0001-7429-3684
P I PradeepkumarDepartment of Chemistry, Indian Institute of Technology Bombay Mumbai 400076 India pradeep@chem.iitb.ac.in.ORCID https://orcid.org/0000-0001-9104-3708
Seergazhi G SrivatsanDepartment of Chemistry, Indian Institute of Science Education and Research (IISER), Pune Dr Homi Bhabha Road Pune 411008 India srivatsan@iiserpune.ac.in.ORCID https://orcid.org/0000-0001-5765-3967

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the structure and recognition of highly conserved regulatory segments of the integrated viral DNA genome that forms unique topologies can greatly aid in devising novel therapeutic strategies to counter chronic infections. In this study, we configured a probe system using highly environment-sensitive nucleoside analogs, 5-fluoro-2'-deoxyuridine (FdU) and 5-fluorobenzofuran-2'-deoxyuridine (FBFdU), to investigate the structural polymorphism of HIV-1 long terminal repeat (LTR) G-quadruplexes (GQs) by fluorescence and

Identifiers

PMID38817587
PMCPMC11134374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.