Evidence map›Paper›PMID 38817197›Full record

ReviewChemical Society reviews2024

Photochemical dearomative skeletal modifications of heteroaromatics.

Peng Ji, Kuaikuai Duan, Menglong Li, Zhiyuan Wang, Xiang Meng, Yueteng Zhang, Wei Wang

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Dearomative Nucleophilic Addition of Lithium Enolates to Electron-Poor Indoles.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng JiDepartment of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, USA. weiwang1@arizona.edu.ORCID http://orcid.org/0000-0001-5507-8321
Kuaikuai DuanTri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, USA.
Menglong LiTianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Science, School of Basic Medicinal Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. yuetengzhang@zzu.edu.cn.
Zhiyuan WangHenan Institute of Advanced Technology, Zhengzhou University, Zhengzhou 450001, China.ORCID http://orcid.org/0000-0001-6986-9589
Xiang MengDepartment of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, USA. weiwang1@arizona.edu.
Yueteng ZhangTianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Science, School of Basic Medicinal Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China. yuetengzhang@zzu.edu.cn.ORCID http://orcid.org/0000-0002-6882-196X
Wei WangDepartment of Pharmacology and Toxicology, R. Ken Coit College of Pharmacy, University of Arizona, USA. weiwang1@arizona.edu.ORCID http://orcid.org/0000-0001-6043-0860

Funding

Organocatalytic Practical Synthesis of Deuterated Building Blocks and Biologically Important StructuresR01GM125920 · NIGMS · UNIVERSITY OF NEW MEXICO · PI WANG, WEI · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM125920
6 · The paper itself

Abstract

Dearomatization has emerged as a powerful tool for rapid construction of 3D molecular architectures from simple, abundant, and planar (hetero)arenes. The field has evolved beyond simple dearomatization driven by new synthetic technology development. With the renaissance of photocatalysis and expansion of the activation mode, the last few years have witnessed impressive developments in innovative photochemical dearomatization methodologies, enabling skeletal modifications of dearomatized structures. They offer truly efficient and useful tools for facile construction of highly complex structures, which are viable for natural product synthesis and drug discovery. In this review, we aim to provide a mechanistically insightful overview on these innovations based on the degree of skeletal alteration, categorized into dearomative functionalization and skeletal editing, and to highlight their synthetic utilities.

Identifiers

PMID38817197
PMCPMC11181993

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.