Evidence map›Paper›PMID 38816935›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Catalytic Dual-Mode Immunotherapy: Anisotropic AuPt Heterostructure Decorated with Starry Pt Nanoclusters for Robust Cancer Photometalloimmunotherapy.

Wei Bian, Xi Hu, Ruixue Xiao, Rui Yao, Bo Zhang, Mingjian Zhu, Tianqi Liu, Yamin Liu, Jing Li, Peihua Lin and 3 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Metallic nanomedicine in cancer immunotherapy.Acta pharmaceutica Sinica. B · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei BianDepartment of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Xi HuSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.ORCID 0000-0002-2533-4408
Ruixue XiaoFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Rui YaoKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, 030000, China.
Bo ZhangFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Mingjian ZhuInstitute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Tianqi LiuKey Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan, 030000, China.
Yamin LiuFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Jing LiDepartment of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Peihua LinFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
An XieSchool of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Fangyuan LiSongjiang Institute and Songjiang Hospital, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Daishun LingFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, School of Biomedical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.ORCID 0000-0002-9977-0237

Funding

Anzhong Scholars Outstanding Talents PlanCAS Interdisciplinary Innovation Team JCTD-2020-08Innovative Research Team of High-Level Local Universities in Shanghai SHSMU-ZDCX20210900Leading Talent of "Ten Thousand P tional High-Level Talents Special Support PlanNational Key Research and Development Program of China 2022YFB3203800National Key Research and Development Program of China 2022YFB3203801National Key Research and Development Program of China 2022YFB3203804National Key Research and Development Program of China 2023YFF0724101National Key Research and Development Program of China 2023YFF0724102National Natural Science Foundation of China 32000985National Natural Science Foundation of China 32071374Natural Science Foundation of Shanxi Province of China 201901D111210Natural Science Foundation of Shanxi Province of China 202203021221186Program of Shanghai Academic Research Leader under the Science and Technology Innovation Action Plan 21XD1422100Program of Shanghai Science and Technology Development 22TS1400700Shanghai Jiao Tong University 22×010201631Shanghai Municipal Health Commission Traditional Chinese Medicine Research Project 2024PT009shanghai Municipal Science and Technology Commission 21dz2210100Zhejiang Provincial Natural Science Foundation of China LQ21H300003Zhejiang Provincial Natural Science Foundation of China LR22C100001
6 · The paper itself

Abstract

To overcome current limitations in photoimmunotherapy, such as insufficient tumor antigen generation and a subdued immune response, a novel photo-/metallo dual-mode immunotherapeutic agent (PMIA) is introduced for potent near-infrared (NIR) light-triggered cancer therapy. PMIA features a dumbbell-like AuPt heterostructure decorated with starry Pt nanoclusters, meticulously engineered for enhancing plasmonic catalysis through multi-dimensional regulation of Pt growth on Au nanorods. Under NIR laser exposure, end-tipped Pt nanoclusters induce efficient electron-hole spatial separation along the longitudinal axis, resulting in radial and axial electron distribution polarization, conferring unique anisotropic properties to PMIA. Additionally, starry Pt nanoclusters on the sides of Au nanorods augment the local electron enrichment field. Validated through finite-difference time-domain analysis and Raman scattering, this configuration fosters local electron enrichment, facilitating robust reactive oxygen species generation for potent photoimmunotherapy. Moreover, Pt nanoclusters facilitate Pt

Indexed as

GoldImmunotherapyMetal NanoparticlesPlatinumAnimalsAnisotropyCatalysisCell Line, TumorDisease Models, AnimalHumansMiceNeoplasmsPhototherapyGoldPlatinumcancer photometalloimmunotherapydumbbell‐like heterostructuresimmunogenic cell deathion releaseplatinum nanoclusters

Identifiers

PMID38816935
PMCPMC11267392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.