Evidence map›Paper›PMID 38816774›Full record

ReviewStem cell research & therapy2024

Bridging the gap between in vitro and in vivo models: a way forward to clinical translation of mitochondrial transplantation in acute disease states.

David F Bodenstein, Gabriel Siebiger, Yimu Zhao, Aaron J Clasky, Avinash N Mukkala, Erika L Beroncal, Lauren Banh, Lili Aslostovar, Sonya Brijbassi, Sarah E Hogan and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  13. What's New in Musculoskeletal Basic Science.The Journal of bone and joint surgery. American volume · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

David F Bodenstein *Department of Pharmacology and Toxicology, University of Toronto, Medical Science Building, Room 4211, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Gabriel Siebiger *Institute of Medical Science (IMS), University of Toronto, Toronto, Canada.
Yimu Zhao *Institute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
Aaron J Clasky *Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Canada.
Avinash N Mukkala *Institute of Medical Science (IMS), University of Toronto, Toronto, Canada.
Erika L Beroncal *Department of Pharmacology and Toxicology, University of Toronto, Medical Science Building, Room 4211, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Lauren Banh *Institute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
Lili AslostovarCentre for Commercialization of Regenerative Medicine, Toronto, Canada.
Sonya BrijbassiMitochondrial Innovation Initiative (MITO2i), Toronto, Canada.
Sarah E HoganRegenerative Medicine Department, United Therapeutics Corporation, Silver Spring, USA.
James D McCullyHarvard Medical School, Boston, USA.
Mohadeseh MehrabianCentre for Commercialization of Regenerative Medicine, Toronto, Canada.
Thomas H PetersenRegenerative Medicine Department, United Therapeutics Corporation, Silver Spring, USA.
Lisa A RobinsonProgram in Cell Biology, The Hospital for Sick Children Research Institute, Toronto, Canada.
Melanie WalkerDepartment of Neurological Surgery, University of Washington, Seattle, USA.
Constantine ZachosMitochondrial Innovation Initiative (MITO2i), Toronto, Canada.
MITO2i-MbD Mitochondrial Transplant Consortium
Sowmya ViswanathanInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
Frank X GuInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
Ori D RotsteinMitochondrial Innovation Initiative (MITO2i), Toronto, Canada.
Marcelo CypelLatner Thoracic Research Laboratories, Toronto General Hospital, Toronto, Canada.
Milica RadisicInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, M5S 3G9, Canada.
Ana C AndreazzaDepartment of Pharmacology and Toxicology, University of Toronto, Medical Science Building, Room 4211, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. ana.andreazza@utoronto.ca.ORCID 0000-0002-4323-7273

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial transplantation and transfer are being explored as therapeutic options in acute and chronic diseases to restore cellular function in injured tissues. To limit potential immune responses and rejection of donor mitochondria, current clinical applications have focused on delivery of autologous mitochondria. We recently convened a Mitochondrial Transplant Convergent Working Group (CWG), to explore three key issues that limit clinical translation: (1) storage of mitochondria, (2) biomaterials to enhance mitochondrial uptake, and (3) dynamic models to mimic the complex recipient tissue environment. In this review, we present a summary of CWG conclusions related to these three issues and provide an overview of pre-clinical studies aimed at building a more robust toolkit for translational trials.

Indexed as

MitochondriaAcute DiseaseAnimalsHumansMitochondrial Replacement TherapyTranslational Research, BiomedicalIschemia–reperfusion injuryJoint-on-a-chipMitochondriaMitochondrial transplantOrgan-on-a-chip

Identifiers

PMID38816774
PMCPMC11140916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.