Evidence map›Paper›PMID 38816738›Full record

ArticleVirology journal2024

Virological evaluation of natural and modified attapulgite against porcine epidemic diarrhoea virus.

Tianmin Wang, Yuan Wen, Bingxu Qian, Fang Tang, Xiaorong Zhang, Xiulong Xu, Yanmin Zhou, Jianjun Dai, Aiqin Wang, Feng Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Frontiers in cellular and infection microbiology · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianmin Wang *MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Yuan Wen *MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Bingxu QianMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Fang TangMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Xiaorong ZhangJiangsu Co-Innovation Center for the Prevention and Control of Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225104, China.
Xiulong XuJiangsu Co-Innovation Center for the Prevention and Control of Animal Infectious Disease and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225104, China.
Yanmin ZhouCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. zhouym@njau.edu.cn.
Jianjun DaiMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Aiqin WangKey Laboratory of Clay Mineral Applied Research of Gansu Province, Center of Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730099, China.
Feng XueMOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. xuefeng@njau.edu.cn.

Funding

he Guidance Foundation, the Sanya Institute of Nanjing Agricultural University Research NAUSY-ZD08Jiangsu Agricultural Science and Technology Innovation Fund CX(21)2038National Key R&D Program 2021YFD1800500
6 · The paper itself

Abstract

backgroundThe Porcine Epidemic Diarrhea Virus (PEDV) has caused significant economic losses in the global swine industry. As a potential drug for treating diarrhea, the antiviral properties of attapulgite deserve further study.

methodsIn this study, various methods such as RT-qPCR, Western blot, viral titer assay, Cytopathic Effect, immunofluorescence analysis and transmission electron microscopy were used to detect the antiviral activity of attapulgite and to assess its inhibitory effect on PEDV.

resultsWhen exposed to the same amount of virus, there was a significant decrease in the expression of the S protein, resulting in a viral titer reduction from 10

conclusionAs a result, Attapulgite powders can trap and adsorb viruses to inhibit PEDV in vitro, leading to loss of viral infectivity. This study provides new materials for the development of novel disinfectants and antiviral additives.

Indexed as

Antiviral AgentsPorcine epidemic diarrhea virusSilicon CompoundsAnimalsChlorocebus aethiopsCoronavirus InfectionsCytopathogenic Effect, ViralMagnesium CompoundsMicroscopy, Electron, TransmissionSwineSwine DiseasesVero CellsViral LoadAntiviral AgentsattapulgiteMagnesium CompoundsSilicon CompoundsAntiviral materialAttapulgitePorcine epidemic diarrhea virusTransmission electron microscopy of viruses

Identifiers

PMID38816738
PMCPMC11137985

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.