ArticleNature communications2024
Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson's disease.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Beyond the role in motor function, entopeduncular nucleus, a critical neural hub in psychiatric disorders and sleep regulation.Annals of medicine · 2026Review
- Altered Excitation-Inhibition Balance and mGluRInternational journal of molecular sciences · 2026Article
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Multitarget brain implants enable generalized decoding of Parkinson's disease symptoms from chronic home recordings.Research square · 2026Article
- The biological clock in parkinson's disease: mechanisms and chronotherapy.NPJ Parkinson's disease · 2026Review
- At-home movement state classification using totally implantable cortical-basal ganglia neural interface.Science advances · 2026Article
- Deep Brain Stimulation Response Circuits in Obsessive-Compulsive Disorder.Biological psychiatry · 2026Review
- Personalized supervised and unsupervised intracranial sleep decoding during deep brain stimulation.NPJ digital medicine · 2026Article
- Pallidal beta power is associated with depression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Deep brain stimulation clinical trials: a framework to accelerate recruitment, retention, and technology translation.Frontiers in human neuroscience · 2026Article
- Proceedings of the 13th annual deep brain stimulation think tank: the evolving landscape.Frontiers in human neuroscience · 2026Review
- A clinical grade neurostimulation implant for hierarchical control of physiological activity.bioRxiv : the preprint server for biology · 2025Article
- Status dystonicus is a distinct state characterized by pallidal beta-band activity.Nature communications · 2025Article
- KNN-based frequency-adjustable ferroelectric heterojunction and biomedical applications.Nature communications · 2025Article
- Article
- Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain-Sense Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.Frontiers in human neuroscience · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Circadian rhythms have been shown in the subthalamic nucleus (STN) in Parkinson's disease (PD), but only a few studies have focused on the globus pallidus internus (GPi). This retrospective study investigates GPi circadian rhythms in a large cohort of subjects with PD (130 recordings from 93 subjects) with GPi activity chronically recorded in their home environment. We found a significant change in GPi activity between daytime and nighttime in most subjects (82.4%), with a reduction in GPi activity at nighttime in 56.2% of recordings and an increase in activity in 26.2%. GPi activity in higher frequency bands ( > 20 Hz) was more likely to decrease at night and in patients taking extended-release levodopa medication. Our results suggest that circadian fluctuations in the GPi vary across individuals and that increased power at night might be due to the reemergence of pathological neural activity. These findings should be considered to ensure successful implementation of adaptive neurostimulation paradigms in the real-world.
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