ArticleNature communications2024
Plasmodium falciparum infection in humans and mosquitoes influence natural Anopheline biting behavior and transmission.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Biannual Mass Azithromycin Distributions for Preschool Children and Malaria Parasitemia: A Secondary Analysis of the MORDOR Cluster Randomized Trial.JAMA network open · 2025Trial
- A randomized controlled trial combining house screening and insecticide-treated nets reduces malaria transmission in northwestern Ethiopia.Scientific reports · 2025Trial
- Mosquito salivary protein antibodies as efficient endpoints for vector control trials: A mechanistic comparison with clinical and entomological outcomes.Infectious Disease Modelling · 2026Article
- A comparison of indoor and outdoor malaria vectors in a longitudinal cohort study in Webuye, Western Kenya.Research square · 2026Article
- Expelling of Plasmodium falciparum Sporozoites by Anopheles stephensi Mosquitoes During Repeated Feeding.The Journal of infectious diseases · 2026Article
- Divergent urban-rural drivers of malaria vector ecology: a 6-year One Health longitudinal study in China.Parasites & vectors · 2026Article
- Behavioral factors associated with artemisinin resistance: linking community treatment practices with pfkelch13 mutations in Northern Uganda.Malaria journal · 2026Article
- Sickle Trait Hemoglobin Does Not Influence Anopheles Biting Rates.The American journal of tropical medicine and hygiene · 2026Article
- Uneven Plasmodium falciparum Transmission and Cryptic ovale Transmission From the Asymptomatic Reservoir in Bagamoyo, Tanzania.The Journal of infectious diseases · 2026Article
- Article
- Sickle-trait hemoglobin does not influencemedRxiv : the preprint server for health sciences · 2025Article
- Marked heterogeneity in malaria infection rate in a Malian longitudinal cohort.Nature communications · 2025Article
- Characterization of Malaria Outbreak in Marsabit County, Kenya, March 2024.The American journal of tropical medicine and hygiene · 2025Article
- Anopheles mosquito exposure is associated with age, gender and bed net use in areas in Uganda experiencing varying malaria transmission intensity.The Journal of infection · 2025Article
- Malaria: past, present, and future.Signal transduction and targeted therapy · 2025Review
- Malaria.The New England journal of medicine · 2025Review
- Global burden of malaria before and after the COVID-19 pandemic based on the global burden of disease study 2021.Scientific reports · 2025Article
- Smartphone conjunctiva photography for malaria risk stratification in asymptomatic school age children.NPJ digital medicine · 2025Article
- Relationship between malaria vector survival, infectivity, and insecticide-treated net use in western Kenya.Parasites & vectors · 2024Article
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Authors and funding
15 authors.
Funding
Abstract
The human infectious reservoir of Plasmodium falciparum is governed by transmission efficiency during vector-human contact and mosquito biting preferences. Understanding biting bias in a natural setting can help target interventions to interrupt transmission. In a 15-month cohort in western Kenya, we detected P. falciparum in indoor-resting Anopheles and human blood samples by qPCR and matched mosquito bloodmeals to cohort participants using short-tandem repeat genotyping. Using risk factor analyses and discrete choice models, we assessed mosquito biting behavior with respect to parasite transmission. Biting was highly unequal; 20% of people received 86% of bites. Biting rates were higher on males (biting rate ratio (BRR): 1.68; CI: 1.28-2.19), children 5-15 years (BRR: 1.49; CI: 1.13-1.98), and P. falciparum-infected individuals (BRR: 1.25; CI: 1.01-1.55). In aggregate, P. falciparum-infected school-age (5-15 years) boys accounted for 50% of bites potentially leading to onward transmission and had an entomological inoculation rate 6.4x higher than any other group. Additionally, infectious mosquitoes were nearly 3x more likely than non-infectious mosquitoes to bite P. falciparum-infected individuals (relative risk ratio 2.76, 95% CI 1.65-4.61). Thus, persistent P. falciparum transmission was characterized by disproportionate onward transmission from school-age boys and by the preference of infected mosquitoes to feed upon infected people.
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