Evidence map›Paper›PMID 38816279›Full record

ArticleTrends in biochemical sciences2024

Subconductance states add complexity to Piezo1 gating model.

Marie E Cronin, Jörg Grandl

Abstract read
In one paragraph

Article in Trends in biochemical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marie E CroninDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Jörg GrandlDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: grandl@neuro.duke.edu.

Funding

Mechanisms of Disease associated with mechanically-activated Piezo ion channelsR01NS110552 · NINDS · DUKE UNIVERSITY · PI GRANDL, JORG · 2020 to 2024
$1.8M
NINDS NIH HHS R01 NS110552
6 · The paper itself

Abstract

Piezos are force-gated ion channels that detect and communicate membrane tension to the cell. Recent work from Ullah, Nosyreva, and colleagues characterizes partial channel openings, known as subconductance states, and develops a new gating model of Piezo1 function.

Indexed as

Ion Channel GatingIon ChannelsAnimalsHumansModels, BiologicalIon ChannelsPIEZO1 protein, humanforce-gated ion channelsgating modelmechanotransductionPiezo channelssubconductance states

Identifiers

PMID38816279
PMCPMC11227380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.