Evidence map›Paper›PMID 38816028›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Widespread reductions in cortical thickness following ketamine abuse.

Jinsong Tang, Qiuxia Wu, Chang Qi, An Xie, Jianbin Liu, Yunkai Sun, Tifei Yuan, Wei Chen, Tieqiao Liu, Wei Hao and 2 more

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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Jinsong TangFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Qiuxia WuFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Chang QiFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
An XieFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Jianbin LiuFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Yunkai SunFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Tifei YuanFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Wei ChenFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Tieqiao LiuFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Wei HaoFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Xu ShaoFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan).
Yanhui LiaoFrom the Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China (Tang, Sun, Chen, Shao, Liao); the Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China (Wu, Liu, Hao); the Department of Psychiatry, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P. R. China (Qi); the Department of Radiology, The People's Hospital of Hunan Province, Changsha, Hunan, P. R. China (Xie, Liu); the Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China (Yuan) liaoyanhui@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsketamine is a version of ketamine that has been approved for treatment-resistant depression, but our previous studies showed a link between non-medical use of ketamine and brain structural and functional alterations, including dorsal prefrontal grey matter reduction among chronic ketamine users. In this study, we sought to determine cortical thickness abnormalities following long-term, non-medical use of ketamine.

methodsWe acquired structural brain images for patients with ketamine use disorder and drug-free healthy controls. We used FreeSurfer software to measure cortical thickness for 68 brain regions. We compared cortical thickness between the 2 groups using analysis of covariance with covariates of age, gender, educational level, smoking, drinking, and whole-brain mean cortical thickness.

resultsWe included images from 95 patients with ketamine use disorder and 169 controls. Compared with healthy controls, patients with ketamine use disorder had widespread decreased cortical thickness, with the most extensive reductions in the frontal (including the dorsolateral prefrontal cortex) and parietal (including the precuneus) lobes. Increased cortical thickness was not observed among ketamine users relative to comparison participants. Estimated total lifetime ketamine consumption was correlated with reductions in the right inferior parietal and the right rostral middle frontal cortical thickness. LIMITATIONS: We conducted a retrospective cross-sectional study, but longitudinal studies are needed to further validate decreased cortical thickness after nonmedical use of ketamine.

conclusionThis study provided evidence that, compared with healthy controls, chronic ketamine users have widespread reductions in cortical thickness. Our study underscores the importance of the long-term effects of ketamine on brain structure and serves as a reference for the antidepressant use of ketamine.

Indexed as

Cerebral CortexKetamineMagnetic Resonance ImagingSubstance-Related DisordersAdultBrain Cortical ThicknessFemaleHumansMaleMiddle AgedYoung AdultEsketamineKetamine

Identifiers

PMID38816028
PMCPMC11149615

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