ArticleAJNR. American journal of neuroradiology2024
Hypoperfusion Intensity Ratio Is Associated with Early Neurologic Deficit Severity and Deterioration after Mechanical Thrombectomy in Large-Vessel Occlusion Ischemic Stroke.
Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hypoperfusion Intensity Ratio as a Predictive Marker in Pre-Endovascular Treatment Perfusion Magnetic Resonance Image for Acute Middle Cerebral Artery Occlusion with Intracranial Atherosclerosis.Cerebrovascular diseases extra · 2026Article
- Novel Computed Tomography Perfusion and Laboratory Indices as Predictors of Long-Term Outcome and Survival in Acute Ischemic Stroke.Neurology international · 2025Article
- From Brain to Insomnia: Can Neurotrophic Factors Unlock the Sleep Puzzle After Stroke? [Letter].Nature and science of sleep · 2025Article
- Association of CT perfusion parameters with outcomes in patients with medium vessel occlusion undergoing endovascular thrombectomy.Therapeutic advances in neurological disorders · 2025Article
- Relative Hypotension is Not Associated with Rapid Progressor Phenotype in Anterior Circulation Large-Vessel Occlusion Acute Ischaemic Stroke: A Retrospective Cohort Study.Cerebrovascular diseases extra · 2025Article
- Napkin-ring sign plaques are associated with clinical outcome in patients with acute ischemic stroke after endovascular therapy.Frontiers in neurologyArticle
- Advances in Collateral Neuroimaging for Acute Ischemic Stroke: Redefining Time and Tissue Windows in the Reperfusion Era.Journal of neuroimaging : official journal of the American Society of NeuroimagingReview
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4 authors.
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Abstract
background and purposeThe hypoperfusion intensity ratio is a surrogate marker for collateral status and a predictor of infarct growth, malignant cerebral edema, and hemorrhagic transformation. Its utility to predict a poor NIHSS score and early neurologic deterioration after mechanical thrombectomy for large vessel (LVO) versus distal and medium vessel occlusions (DMVO) has not been investigated. The objective of this study was to determine whether the higher hypoperfusion intensity ratio is associated with a worse NIHSS score at 24 hours post-mechanical thrombectomy and early neurologic deterioration in LVO versus DMVO acute ischemic stroke. MATERIALS AND
methodsThis was a retrospective study of 231 patients with acute ischemic stroke with LVO or DMVO amenable for mechanical thrombectomy and available CTP for hypoperfusion intensity ratio assessment pre-mechanical thrombectomy. Clinical and imaging characteristics were abstracted from the medical records. The primary outcome was the NIHSS score at 24 hours post-mechanical thrombectomy. The secondary outcome was early neurologic deterioration, defined as a >4-point increase in the NIHSS score between the initial assessment and 24 hours post-mechanical thrombectomy. All analyses were first conducted in the entire cohort and then separately for the LVO versus DMVO groups.
resultsThe optimal hypoperfusion intensity ratio threshold to detect early neurologic deterioration was 0.54. A hypoperfusion intensity ratio ≥ 0.54 was more frequently present in LVO versus DMVO (
conclusionsThe hypoperfusion intensity ratio ≥ 0.54 was independently associated with a worse 24-hour post-mechanical thrombectomy NIHSS score and early neurologic deterioration in LVO, but not in DMVO acute ischemic stroke. Pending confirmation in future, prospective studies assessing the hypoperfusion intensity ratio may help identify patients at risk of secondary decline to improve peri-thrombectomy care and clinical decision-making.
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