Evidence map›Paper›PMID 38815859›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2024

Socioeconomic Disadvantage Moderates the Association of Systemic Inflammation With Amygdala Volume in Adolescents Over a 2-Year Interval: An Exploratory Study.

Justin P Yuan, Emma L Jaeger, Saché M Coury, Jessica P Uy, Jessica L Buthmann, Tiffany C Ho, Ian H Gotlib

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justin P YuanDepartment of Psychology, Stanford University, Stanford, California. Electronic address: yuanjp@stanford.edu.
Emma L JaegerDepartment of Psychology, Stanford University, Stanford, California.
Saché M CouryDepartment of Psychology, Stanford University, Stanford, California; Department of Psychology, University of California, Los Angeles, Los Angeles, California.
Jessica P UyDepartment of Psychology, Stanford University, Stanford, California.
Jessica L ButhmannDepartment of Psychology, Stanford University, Stanford, California.
Tiffany C HoDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, California.

Funding

Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
The Effects of Early Life Stress on Neurodevelopment in Children and AdolescentsR01MH101495 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 2013 to 2016
$2.9M
The Roles of Inflammatory and Glutamatergic Processes in the Neurodevelopmental Mechanisms Underlying Adolescent DepressionK01MH117442 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, TIFFANY CHEING · 2018 to 2022
$881k
Effects of Early Life Stress and Sleep Disturbance on Frontolimbic Development and Risk for Depression Across AdolescenceF32MH135657 · NIMH · STANFORD UNIVERSITY · PI UY, JESSICA PHUONG · 2023 to 2025
$242k
NIMH NIH HHS F32 MH135657NIMH NIH HHS K01 MH117442NIMH NIH HHS R01 MH101495NIMH NIH HHS R37 MH101495
6 · The paper itself

Abstract

backgroundResearch has demonstrated an association between elevated systemic inflammation and changes in brain function. Affective areas of the brain involved in processing threat (e.g., amygdala) and reward (e.g., nucleus accumbens) appear to be sensitive to inflammation. Early-life stress, such as experiencing low socioeconomic status (SES), may also potentiate this association, but relevant evidence has come primarily from cross-sectional studies of brain function. It is unclear whether similar associations are present between early-life stress, inflammation, and brain structure, particularly in typically developing populations.

methodsWe recruited and assessed 50 adolescents (31 females/19 males) from the community (mean [SD] age = 15.5 [1.1] years, range = 13.1-17.5 years) and examined in exploratory analyses whether changes in C-reactive protein (ΔCRP) from blood spots predict changes in gray matter volume (ΔGMV) in the bilateral amygdala and nucleus accumbens over a 2-year period. We also investigated whether experiencing early-life stress, operationalized using a comprehensive composite score of SES disadvantage at the family and neighborhood levels, significantly moderated the association between ΔCRP and ΔGMV.

resultsWe found that ΔCRP was negatively associated with Δamygdala GMV (i.e., increasing CRP levels were associated with decreasing amygdala volume; β = -0.84, p = .012). This effect was stronger in youths who experienced greater SES disadvantage (β = -0.56, p = .025).

conclusionsThese findings suggest that increases in systemic inflammation are associated with reductions in amygdala GMV in adolescents, potentially signaling accelerated maturation, and that these neuroimmune processes are compounded in adolescents who experienced greater SES disadvantage. Our findings are consistent with theoretical frameworks of neuroimmune associations and suggest that they may influence adolescent neurodevelopment.

Indexed as

AmygdalaInflammationMagnetic Resonance ImagingAdolescentC-Reactive ProteinFemaleGray MatterHumansMaleNucleus AccumbensSocial ClassSocioeconomic Disparities in HealthStress, PsychologicalC-Reactive ProteinAdolescent developmentAdversityBrain structureEarly stressInflammationMRI

Identifiers

PMID38815859
PMCPMC11381175

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.