ReviewJournal of innate immunity2024
Unraveling the Intricate Web: Complement Activation Shapes the Pathogenesis of Sepsis-Induced Coagulopathy.
Review in Journal of innate immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Venous Thromboembolism in Severe Community-Acquired Pneumonia at High-Altitude Areas: Prevalence, Risk and Outcome.The clinical respiratory journal · 2026Article
- Epigenetic Mechanisms in Perioperative Medicine: From Neuroinflammation and NETosis to Organ Dysfunction and Precision Therapeutics.Biomedicines · 2026Review
- Establishment and validation of a machine learning-based prediction model for sepsis-induced coagulopathy.Journal of thrombosis and thrombolysis · 2026Article
- Integrative metabolite-protein interaction networks reveal potential pathways and biomarkers in sepsis.BMC infectious diseases · 2026Article
- Hyper-inflammation and immunosuppression: redefining sepsis therapy using modern approaches.Frontiers in pharmacology · 2026Review
- Sepsis-induced immunothrombosis: from cellular crosstalk to multiple organ dysfunction.Frontiers in immunology · 2026Review
- Article
- Machine learning-based transcriptomic analysis identifies candidate genes in sepsis-induced coagulopathy and explores the immunomodulatory potential of baicalein.Human genomics · 2025Article
- Disseminated intravascular coagulation.Journal of intensive care · 2025Review
- Relation between serum magnesium and outcome in patients with Escherichia coli sepsis.BMC infectious diseases · 2025Article
- Relationship between coagulopathy score and survival in critically ill patients with liver cirrhosis and sepsis: a retrospective study.BMC infectious diseases · 2025Article
- Comparative safety analysis of Riluzole, Edaravone and Tofersen in ALS management: insights from FAERS database.Frontiers in pharmacology · 2025Article
- Aspirin is associated with a reduction in mortality rate for patients with sepsis-induced coagulopathy: a retrospective cohort study.Frontiers in pharmacology · 2025Article
- Global Research Trends in Sepsis-Associated Coagulopathy: A Web of Science-Based Bibliometric Analysis (2000-2024).Journal of multidisciplinary healthcare · 2025Review
- Development and validation of a machine-learning-based model for identification of genes associated with sepsis-associated acute kidney injury.Frontiers in genetics · 2025Article
- The dysfunction of complement and coagulation in diseases: the implications for the therapeutic interventions.MedComm · 2024Review
- Immunometabolites Direct the Pathogenesis of Bacterial Infection.Journal of innate immunity · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis-associated coagulopathy specifically refers to widespread systemic coagulation activation accompanied by a high risk of hemorrhage and organ damage, which in severe cases manifests as disseminated intravascular coagulation (DIC), or even develops into multiple organ dysfunction syndrome (MODS). The complement system and the coagulation system as the main columns of innate immunity and hemostasis, respectively, undergo substantial activation after sepsis. SUMMARY: Dysfunction of the complement, coagulation/fibrinolytic cascades caused by sepsis leads to "thromboinflammation," which ultimately amplifies the systemic inflammatory response and accelerates the development of MODS. Recent studies have revealed that massive activation of the complement system exacerbates sepsis-induced coagulation and even results in DIC, which suggests that inhibition of complement activation may have therapeutic potential in the treatment of septic coagulopathy. KEY MESSAGES: Sepsis-associated thrombosis involves the upregulation or activation of procoagulant factors, down-regulation or inactivation of anticoagulant factors, and impairment of the fibrinolytic mechanism. This review aims to summarize the latest literature and analyze the underlying molecular mechanisms of the activation of the complement system on the abnormal coagulation cascades in sepsis.
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