Evidence map›Paper›PMID 38815251›Full record

ReviewAdvanced healthcare materials2024

Imaging-Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids.

Seong-Eun Kim, Suji Yun, Junsang Doh, Hong Nam Kim

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Seong-Eun KimBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, South Korea.
Suji YunInterdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826, South Korea.
Junsang DohInterdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826, South Korea.
Hong Nam KimBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, South Korea.ORCID 0000-0002-0329-0029

Funding

Korea Institute of Science and Technology program 2E32911Ministry of Science and ICTNational Research Foundation of Korea NRF-2022M3A9B6082678National Research Foundation of Korea RS-2023-00208359National Research Foundation of Korea RS-2023-00217061National Research Foundation of Korea RS-2023-00218543National Research Foundation of Korea RS-2023-00222838National Research Foundation of Korea RS-2023-00273442
6 · The paper itself

Abstract

Cancer immunotherapy is used to treat tumors by modulating the immune system. Although the anticancer efficacy of cancer immunotherapy has been evaluated prior to clinical trials, conventional in vivo animal and endpoint models inadequately replicate the intricate process of tumor elimination and reflect human-specific immune systems. Therefore, more sophisticated models that mimic the complex tumor-immune microenvironment must be employed to assess the effectiveness of immunotherapy. Additionally, using real-time imaging technology, a step-by-step evaluation can be applied, allowing for a more precise assessment of treatment efficacy. Here, an overview of the various imaging-based evaluation platforms recently developed for cancer immunotherapeutic applications is presented. Specifically, a fundamental technique is discussed for stably observing immune cell-based tumor cell killing using direct imaging, a microwell that reproduces a confined space for spatial observation, a droplet assay that facilitates cell-cell interactions, and a 3D microphysiological system that reconstructs the vascular environment. Furthermore, it is suggested that future evaluation platforms pursue more human-like immune systems.

Indexed as

ImmunotherapyNeoplasmsOrganoidsTumor MicroenvironmentAnimalsHumansbioimagingcancer immunotherapyefficacy evaluationengineered tumor platformtumor organoid

Identifiers

PMID38815251
PMCPMC12344649

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.