Evidence map›Paper›PMID 38815127›Full record

ArticleACS applied materials & interfaces2024

Crystal Clear: Metal-Organic Frameworks Pioneering the Path to Future Drug Detox.

Przemysław J Jodłowski, Klaudia Dymek, Grzegorz Kurowski, Kornelia Hyjek, Anna Boguszewska-Czubara, Barbara Budzyńska, Weronika Mrozek, Norbert Skoczylas, Łukasz Kuterasiński, Witold Piskorz and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Formulation and Delivery Systems of Cocaine and Methamphetamine Scent Mimics.International journal of analytical chemistry · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Przemysław J JodłowskiFaculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, Kraków 31-155, Poland.ORCID 0000-0003-2554-6539
Klaudia DymekFaculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, Kraków 31-155, Poland.
Grzegorz KurowskiFaculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, Kraków 31-155, Poland.
Kornelia HyjekFaculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, Kraków 31-155, Poland.
Anna Boguszewska-CzubaraDepartment of Medical Chemistry, Medical University of Lublin, Chodzki 4A, Lublin 20-093, Poland.
Barbara BudzyńskaIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Chodzki 4A, Lublin 20-093, Poland.
Weronika MrozekIndependent Laboratory of Behavioral Studies, Medical University of Lublin, Chodzki 4A, Lublin 20-093, Poland.
Norbert SkoczylasFaculty of Geology, Geophysics and Environmental Protection, AGH University of Krakow, Mickiewicza 30, Kraków 30-059, Poland.
Łukasz KuterasińskiJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, Kraków 30-239, Poland.ORCID 0000-0002-0498-1120
Witold PiskorzFaculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, Kraków 30-387, Poland.ORCID 0000-0002-3462-436X
Marek BiałoruskiFaculty of Chemistry, Jagiellonian University in Kraków, Gronostajowa 2, Kraków 30-387, Poland.
Roman J JędrzejczykMałopolska Centre of Biotechnology, Jagiellonian University in Kraków, Gronostajowa 7A, Kraków 30-387, Poland.
Piotr JeleńFaculty of Materials Science and Ceramics, AGH University of Krakow, Mickiewicza 30, Kraków 30-059, Poland.
Maciej SitarzFaculty of Materials Science and Ceramics, AGH University of Krakow, Mickiewicza 30, Kraków 30-059, Poland.ORCID 0000-0002-8339-2710

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing number of acute drug abuse overdoses demands the development of innovative detoxification strategies for emergency purposes. In this study, an innovative approach for the application of porous Zr-based metal-organic frameworks for the treatment of acute overdoses of popular drugs of abuse including amphetamine, methamphetamine, cocaine, and MDMA is presented. A comprehensive approach determining the efficacy and the kinetics of drug removal, considering dosage, adsorption time, and adsorption mechanisms, was tested and corroborated with density functional theory (DFT) modeling. The experimental results showed high removal efficiency reaching up to 90% in the case of the application of the NU-1000 metal-organic framework. The difference Raman spectroscopy method presented in this study corroborated with DFT-based vibrational analysis allows the detection of drug adsorbed in the MOF framework even with as low a concentration as 5 mg/g. Additionally, the drug adsorption mechanisms were modeled with DFT, showing the π-π stacking in a vast majority of considered cases. The performance and influence on the living organisms were evaluated throughout the

Indexed as

Metal-Organic FrameworksZirconiumAdsorptionAnimalsDensity Functional TheoryMethamphetaminePorosityMetal-Organic FrameworksMethamphetamineZirconiumamphetaminecocainein vivoMDMAmetal−organic frameworks

Identifiers

PMID38815127
PMCPMC11181303

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.