Evidence map›Paper›PMID 38814827›Full record

Trial reportSleep2024

Wireless wearable sensors can facilitate rapid detection of sleep apnea in hospitalized stroke patients.

Jacob Sindorf, Alison L Szabo, Megan K O'Brien, Aashna Sunderrajan, Kristen L Knutson, Phyllis C Zee, Lisa Wolfe, Vineet M Arora, Arun Jayaraman

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04254484 (SIESTA), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04254484 nacompletednot on this map

SIESTA (Sleep of Inpatients: Empower Staff to Act) for Acute Stroke Rehabilitation

TypeinterventionalSponsorUniversity of ChicagoRan2020 to 2025Enrolled400ConditionsSleep, Sleep Disordered Breathing, StrokeArmsSIESTA Rehab Education, ApneaLink
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Comparison of Sleep Architecture in Individuals Aged 65 to 80 Years With and Without Mild Cognitive Impairment Using Multi-Channel Sleep Monitoring.Medical science monitor : international medical journal of experimental and clinical research · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jacob SindorfMax Nader Center for Rehabilitation Technologies and Outcomes Research, Shirley Ryan AbilityLab, Chicago, IL, USA.ORCID 0009-0000-9570-3953
Alison L SzaboFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-4557-4492
Megan K O'BrienMax Nader Center for Rehabilitation Technologies and Outcomes Research, Shirley Ryan AbilityLab, Chicago, IL, USA.
Aashna SunderrajanDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Kristen L KnutsonFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-2751-6168
Phyllis C ZeeFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lisa WolfeFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Vineet M AroraDepartment of Medicine, University of Chicago Medicine, Chicago, IL, USA.
Arun JayaramanMax Nader Center for Rehabilitation Technologies and Outcomes Research, Shirley Ryan AbilityLab, Chicago, IL, USA.ORCID 0000-0002-9302-6693

Funding

PATHOPHYSIOLOGY AND REHABILITATION OF NEURAL DYSFUNCTIONT32HD007418 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Levi John Hargrove · 1992 to 2026
$6.5M
SIESTA (Sleep of Inpatients: Empower Staff to Act) for Acute Stroke Rehabilitation - Resubmission 01R01HD097786 · NICHD · UNIVERSITY OF CHICAGO · PI ARORA, VINEET, JAYARAMAN, ARUN · 2020 to 2024
$3.7M
NICHD NIH HHS R01 HD097786NICHD NIH HHS T32 HD007418NIH HHS R01HD097786
6 · The paper itself

Abstract

STUDY

objectivesTo evaluate wearable devices and machine learning for detecting sleep apnea in patients with stroke at an acute inpatient rehabilitation facility (IRF).

methodsA total of 76 individuals with stroke wore a standard home sleep apnea test (ApneaLink Air), a multimodal, wireless wearable sensor system (ANNE), and a research-grade actigraphy device (ActiWatch) for at least 1 night during their first week after IRF admission as part of a larger clinical trial. Logistic regression algorithms were trained to detect sleep apnea using biometric features obtained from the ANNE sensors and ground truth apnea rating from the ApneaLink Air. Multiple algorithms were evaluated using different sensor combinations and different apnea detection criteria based on the apnea-hypopnea index (AHI ≥ 5, AHI ≥ 15).

resultsSeventy-one (96%) participants wore the ANNE sensors for multiple nights. In contrast, only 48 participants (63%) could be successfully assessed for obstructive sleep apnea by ApneaLink; 28 (37%) refused testing. The best-performing model utilized photoplethysmography (PPG) and finger-temperature features to detect moderate-severe sleep apnea (AHI ≥ 15), with 88% sensitivity and a positive likelihood ratio (LR+) of 44.00. This model was tested on additional nights of ANNE data achieving 71% sensitivity (10.14 LR+) when considering each night independently and 86% accuracy when averaging multi-night predictions.

conclusionsThis research demonstrates the feasibility of accurately detecting moderate-severe sleep apnea early in the stroke recovery process using wearable sensors and machine learning techniques. These findings can inform future efforts to improve early detection for post-stroke sleep disorders, thereby enhancing patient recovery and long-term outcomes. CLINICAL TRIAL: SIESTA (Sleep of Inpatients: Empower Staff to Act) for Acute Stroke Rehabilitation, https://clinicaltrials.gov/study/NCT04254484?term=SIESTA&checkSpell=false&rank=1, NCT04254484.

Indexed as

Sleep Apnea SyndromesStrokeWearable Electronic DevicesActigraphyAgedAlgorithmsFemaleHospitalizationHumansMachine LearningMaleMiddle AgedPhotoplethysmographyPolysomnographyWireless Technologymachine learningobstructive sleep apneasleep apnea screeningstroke

Identifiers

PMID38814827
PMCPMC11543614

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.