Evidence map›Paper›PMID 38814789›Full record

ArticleJournal of bacteriology2024

Prevalence of Slam-dependent hemophilins in Gram-negative bacteria.

Hyejin Esther Shin, Chuxi Pan, David M Curran, Thomas J Bateman, Derrick H Y Chong, Dixon Ng, Megha Shah, Trevor F Moraes

Abstract read
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Cervicovaginal microbial features predictInfection and immunity · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyejin Esther ShinDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-3537-3184
Chuxi PanDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
David M CurranDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Thomas J BatemanDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Derrick H Y ChongDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Dixon NgDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Megha ShahDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Trevor F MoraesDepartment of Biochemistry, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-9883-6145

Funding

Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-148795, PJT-480213
6 · The paper itself

Abstract

Iron acquisition systems are crucial for pathogen growth and survival in iron-limiting host environments. To overcome nutritional immunity, bacterial pathogens evolved to use diverse mechanisms to acquire iron. Here, we examine a heme acquisition system that utilizes hemophores called hemophilins which are also referred to as HphAs in several Gram-negative bacteria. In this study, we report three new HphA structures from IMPORTANCE: This paper describes the structure and function of a family of Slam (Type IX secretion System) secreted hemophores that bacteria use to uptake heme (iron) while establishing an infection. Using structure-based bioinformatics analysis to define the diversity and prevalence of this heme acquisition pathway, we discovered that a large portion of gammaproteobacterial harbors this system. As organisms, including

Indexed as

Bacterial ProteinsGram-Negative BacteriaHemeIronBacterial ProteinsHemeIronGram-negative bacteriaheme transportouter membrane proteinsX-ray crystallography

Identifiers

PMID38814789
PMCPMC11332172

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.