Evidence map›Paper›PMID 38814564›Full record

ArticleAnnals of nuclear medicine2024

DOCK-PET: database of CNS kinetic parameters in the healthy human brain for existing PET tracers.

Itsuki Miyajima, Ayano Yoshikawa, Kyosei Sahashi, Chie Seki, Yuji Nagai, Hiroshi Watabe, Miho Shidahara

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Article in Annals of nuclear medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Itsuki MiyajimaDepartment of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan.
Ayano YoshikawaDepartment of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan.
Kyosei SahashiDepartment of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan.
Chie SekiAdvanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Yuji NagaiAdvanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan.
Hiroshi WatabeDivision of Radiation Protection and Nuclear Safety, Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan.
Miho ShidaharaDepartment of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan. miho.shidahara.c2@tohoku.ac.jp.ORCID http://orcid.org/0000-0003-3647-2299

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInformation about developed positron emission tomography (PET) tracers and obtained clinical PET images is publicly available in a database. However, findings regarding the kinetic parameters of PET tracers are yet to be summarized. Therefore, in this study, we created an open-access database of central nervous system (CNS) kinetic parameters in the healthy human brain for existing PET tracers (DOCK-PET).

methodsOur database includes information on the kinetic parameters and compounds of existing CNS-PET tracers. The kinetic parameter dataset comprises the analysis methods, V

resultsOf the 247 PET tracers identified through searches using the PubMed and MICAD websites, the kinetic parameters of 120 PET tracers were available. Among the 120 PET tracers, compound structures with chemical and physical properties were obtained from the PubChem website or the ChemDraw software. Furthermore, the affinity information of the 104 PET tracers was gathered from PubChem or extensive literature surveys of the 120 PET tracers.

conclusionsWe developed a comprehensive open-access database, DOCK-PET, that includes both kinetic parameters of healthy humans and compound information for existing CNS-PET tracers.

Indexed as

BrainDatabases, FactualPositron-Emission TomographyCentral Nervous SystemHumansKineticsRadioactive TracersRadioactive TracersCNS–PETDatabaseHealthy human brainKinetic parameters

Identifiers

PMID38814564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.