ArticleJapanese journal of ophthalmology2024
Comparative features of superior versus inferior hemisphere microvasculature dropout in open-angle glaucoma.
Article in Japanese journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Longitudinal hemifield-specific macular ganglion cell complex thinning and its association with arterial stiffness in eyes without baseline glaucomatous abnormalities.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Ocular Blood Flow in Eyes with Myopia and Glaucoma: From Pathophysiology to Clinical Implications.Journal of clinical medicine · 2026Review
- Combining structural and microvascular parameters via machine learning for enhanced diagnosis of normal-tension glaucoma among highly myopic eyes: a prospective cross-sectional diagnostic accuracy study.BMC ophthalmology · 2026Article
- Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study.Investigative ophthalmology & visual science · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
purposeThis study aimed to investigate differences in microvasculature dropout (MvD) between the superior and inferior hemispheres in glaucoma patients. STUDY
designRetrospective and cross-sectional.
methodsFifty-eight eyes of 58 open-angle glaucoma patients (age 61.12 ± 10.19 years, mean deviation - 7.32 ± 6.36 dB) were included. MvD was detected with en face images from swept-source optical coherence tomography angiography. Blood flow at the optic nerve head was measured with laser speckle flowgraphy, represented as the mean blur rate in tissue (MBRT). Logistic and linear regression models adjusted for age, intraocular pressure, axial length, and circumpapillary retinal nerve fiber layer thickness were used to investigate the relationship between various factors and MvD angle in each hemisphere.
resultsThe presence of inferior MvD was related to peripapillary atrophy-β area (odds ratio = 14.10 [2.49-234.00], P = 0.019). Superior MvD angle was significantly related to MBRT in the superior quadrant (β = -0.31 [- 0.60 - -0.02], P = 0.037). Inferior MvD angle was significantly related to peripapillary atrophy-β area (β = 0.49 [0.21-0.77], P = 0.001).
conclusionsOnly superior MvD demonstrated a significant relationship with reduced ocular blood flow. In contrast, inferior MvD was associated with mechanical stress. These findings may suggest a potential difference in pathophysiology between superior and inferior MvD.
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