Evidence map›Paper›PMID 38814484›Full record

ArticleParasitology research2024

Analysis of lncRNA-related studies of ivermectin-sensitive and -resistant strains of Haemonchus contortus.

Yanmin Zhang, Wenrui Guo, Haifeng Wen, Yaqin Shi, Wa Gao, Xindi Chen, Tengyu Wang, Wenlong Wang, Weijie Wu

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Article in Parasitology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yanmin ZhangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, China.
Wenrui GuoCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, China.
Haifeng WenCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, China.
Yaqin ShiCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, China.
Wa GaoInner Mongolia Key Laboratory of Tick-Borne Infectious Diseases, Inner Mongolia, China.
Xindi ChenCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, China.
Tengyu WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, China.
Wenlong WangCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, China. wwl.imau@163.com.
Weijie WuHinggan League Agricultural and Animal Husbandry Technology Extension Centre, Ulanhot, China. wwjnmj@163.com.

Funding

Monitoring and Deworming of Major Parasitic Diseases in Sheep in Hinggan League MB202306"Science and Technology for the Development of Mongolia" initiative priority program NMKJXM202203
6 · The paper itself

Abstract

In this study, 858 novel long non-coding RNAs (lncRNAs) were predicted as sensitive and resistant strains of Haemonchus contortus to ivermectin. These lncRNAs underwent bioinformatic analysis. In total, 205 lncRNAs significantly differed using log2 (difference multiplicity) > 1 or log2 (difference multiplicity) <  - 1 and FDR < 0.05 as the threshold for significant difference analysis. We selected five lncRNAs based on significant differences in expression, cis-regulation, and their association with the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathways. These expressions of lncRNAs, namely MSTRG.12610.1, MSTRG.8169.1, MSTRG.6355.1, MSTRG.980.1, and MSTRG.9045.1, were significantly downregulated. These findings were consistent with the results of transcriptomic sequencing. We further investigated the relative expression of target gene mRNAs and the regulation of mRNA and miRNA, starting with lncRNA cis-regulation of mRNA, and constructed a lncRNA-mRNA-miRNA network regulation. After a series of statistical analyses, we finally screened out UGT8, Unc-116, Fer-related kinase-1, GGPP synthase 1, and sart3, which may be involved in developing drug resistance under the regulation of their corresponding lncRNAs. The findings of this study provide a novel direction for future studies on drug resistance targets.

Indexed as

Drug ResistanceHaemonchusIvermectinRNA, Long NoncodingAnimalsAnthelminticsComputational BiologyGene Expression ProfilingGene Expression RegulationHaemonchiasisMicroRNAsAnthelminticsIvermectinMicroRNAsRNA, Long NoncodingCis-regulationDrug resistantHaemonchus contortusIvermectinlncRNAqRT-PCR

Identifiers

PMID38814484

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.