Evidence map›Paper›PMID 38814196›Full record

Trial reportEuropean journal of physical and rehabilitation medicine2024

A randomized controlled trial on the effects of traditional Thai mind-body exercise (Ruesi Dadton) on biomarkers in mild cognitive impairment.

Phaksachiphon Khanthong, Kusuma Sriyakul, Ananya Dechakhamphu, Aungkana Krajarng, Chuntida Kamalashiran, Vadhana Jayathavaj, Parunkul Tungsukruthai

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of physical and rehabilitation medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Phaksachiphon KhanthongChulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Kusuma SriyakulChulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Ananya DechakhamphuFaculty of Thai Traditional Medicine and Alternative Medicine, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand.
Aungkana KrajarngChulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Chuntida KamalashiranChulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Vadhana JayathavajFaculty of Allied Health Sciences, Pathumthani University, Pathum Thani, Thailand.
Parunkul TungsukruthaiChulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand - parunkul@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise has been shown to reduce the rate of mild cognitive impairment (MCI) and Alzheimer's disease. Although motor coordination movements and poses in Ruesi Dadton (RD) exercises may improve cognitive function, RD is rarely used for MCI. To date, there is insufficient evidence on whether 12 weeks of RD exercise correlates with blood biomarkers related to neurogenesis and plasticity.

aimTo determine the effects on blood biomarkers of 12-week RD in MCI.

designTwo-group parallel randomized controlled trial.

settingCommunity exercise. POPULATION: Individual with MCI.

methodsFifty-eight participants (n.=29 in each group). The RD group performed 60min of RD exercises (15 poses) three times weekly for 12 weeks. The control group received no intervention. In addition, both groups were given information regarding MCI symptoms by the physician on the first day. Peripheral blood was collected to measure serum brain-derived neurotrophic factor (BDNF) and sirtuin 1 (SIRT1) levels before and after intervention.

resultsThe effects of 12-week RD pre- and post-intervention were examined using 2×2 repeated multivariate analyses, which showed significant differences in interaction by group and time. Student's t-tests and paired t-tests were employed in subsequent analyses to evaluate between-group and within-group differences for both biomarkers.

conclusionsIn each test, we discovered increased levels of BDNF and SIRT1 in the RD group but not in the control group. These findings suggested that RD could benefit MCI patients through enhanced BDNF and SIRT1 levels. CLINICAL REHABILITATION IMPACT: Twelve weeks of RD might be helpful to patients with MCI and older people who experience cognitive impairment by improving blood biomarkers responsible for brain plasticity and amyloid plaque degradation.

Indexed as

BiomarkersBrain-Derived Neurotrophic FactorCognitive DysfunctionExercise TherapyAgedFemaleHumansMaleMiddle AgedMind-Body TherapiesSirtuin 1ThailandBiomarkersBrain-Derived Neurotrophic FactorSirtuin 1

Identifiers

PMID38814196
PMCPMC11403630

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.