Evidence map›Paper›PMID 38814066›Full record

ArticleJournal of virology2024

Higher HIV-1 evolutionary rate is associated with cytotoxic T lymphocyte escape mutations in infants.

Jamirah Nazziwa, Sophie M Andrews, Mimi M Hou, Christian A W Bruhn, Miguel A Garcia-Knight, Jennifer Slyker, Sarah Hill, Barbara Lohman Payne, Dorothy Moringas, Philippe Lemey and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jamirah NazziwaDepartment of Translational Medicine, Lund University, Lund, Sweden.ORCID 0000-0001-9029-7976
Sophie M AndrewsNuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Mimi M HouNuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Christian A W BruhnDepartment of Translational Medicine, Lund University, Lund, Sweden.
Miguel A Garcia-KnightNuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Jennifer SlykerDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Sarah HillDepartment of Pathobiology and Population Sciences, Royal Veterinary College, London, United Kingdom.
Barbara Lohman PayneDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Dorothy MoringasDepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Philippe LemeyDepartment of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Sarah L Rowland-Jones *Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Joakim Esbjörnsson *Department of Translational Medicine, Lund University, Lund, Sweden.ORCID 0000-0002-6088-7796

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
British HIV Association (BHIVA) BH14HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01-HD023412 K24-HD054314NIAID NIH HHS P30 AI027757NICHD NIH HHS K24 HD054314NICHD NIH HHS R01 HD023412Rosetrees Trust (Rosetrees) M403Vetenskapsrådet (VR) 2016-01417Wellcome TrustWellcome Trust (WT) 089567/Z/09/Z
6 · The paper itself

Abstract

Escape from cytotoxic T lymphocyte (CTL) responses toward HIV-1 Gag and Nef has been associated with reduced control of HIV-1 replication in adults. However, less is known about CTL-driven immune selection in infants as longitudinal studies of infants are limited. Here, 1,210

Indexed as

Evolution, Moleculargag Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsInfectious Disease Transmission, VerticalMutationnef Gene Products, Human Immunodeficiency VirusT-Lymphocytes, CytotoxicAdultFemaleHumansImmune EvasionInfantInfant, NewbornLongitudinal StudiesMalegag Gene Products, Human Immunodeficiency Virusnef Gene Products, Human Immunodeficiency VirusCTL responsesdisease progressionHIV-1infantintra-host evolutionvertical transmission

Identifiers

PMID38814066
PMCPMC11265422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.