ArticleEpilepsia open2024
Functional analysis of epilepsy-associated GABA
Article in Epilepsia open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Bridging the Gap: Harnessing Phytochemical-Loaded Nanocarriers for Enhanced Epilepsy Treatment.Molecular neurobiology · 2026Review
- CeDNe: A multi-scale computational framework for modeling structure-function relationships in thebioRxiv : the preprint server for biology · 2025Article
- Functional analysis of epilepsy-associated GABAEpilepsia open · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveGABA
methodsCRISPR-Cas9 gene editing was used to create a complete deletion of unc-49, a C. elegans GABA
resultsNematodes with a full genetic deletion of the entire unc-49 locus were compared with existing unc-49 mutations in three separate phenotypic assays-coordinated locomotion, shrinker frequency and seizure-like convulsions. The full unc-49 deletion exhibited reduced locomotion and increased shrinker frequency and PTZ-induced convulsions, but were not found to be phenotypically stronger than existing unc-49 mutations. Rescue with the unc-49B subunit or creation of humanized worms for the GABA SIGNIFICANCE: These findings establish C. elegans as a genetic model to investigate GABA PLAIN LANGUAGE SUMMARY: Epilepsy is a complex human disease that can be caused by mutations in specific genes. Many possible mutations have been identified, but it is unknown for most of them whether they cause the disease. We tested the role of mutations in one specific gene using a small microscopic worm as an animal model. Our results establish this worm as a model for epilepsy and confirm that the two unknown mutations are likely to cause the disease.
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Registered trials
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