Evidence map›Paper›PMID 38813868›Full record

ArticleeLife2024

Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth.

Ruby Oberin, Sigrid Petautschnig, Ellen G Jarred, Zhipeng Qu, Tesha Tsai, Neil A Youngson, Gabrielle Pulsoni, Thi T Truong, Dilini Fernando, Heidi Bildsoe and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ruby Oberin *Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Sigrid Petautschnig *Centre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Ellen G JarredCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.ORCID https://orcid.org/0000-0002-5394-9995
Zhipeng QuDepartment of Molecular and Biomedical Sciences, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Tesha TsaiCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Neil A YoungsonCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Gabrielle PulsoniCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Thi T TruongSchool of BioSciences, University of Melbourne, Parkville, Australia.
Dilini FernandoCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Heidi BildsoeCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Rheannon O BlücherCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.
Maarten van den BuuseSchool of Psychology and Public Health, La Trobe University, Melbourne, Australia.
David K GardnerSchool of BioSciences, University of Melbourne, Parkville, Australia.ORCID https://orcid.org/0000-0003-3138-8274
Natalie A SimsBone Cell Biology and Disease Unit, St. Vincent's Institute of Medical Research and Department of Medicine at St. Vincent's Hospital, University of Melbourne, Fitzroy, Australia.ORCID https://orcid.org/0000-0003-1421-8468
David L AdelsonDepartment of Molecular and Biomedical Sciences, School of Biological Sciences, University of Adelaide, Adelaide, Australia.ORCID https://orcid.org/0000-0003-2404-5636
Patrick S WesternCentre for Reproductive Health, Hudson Institute of Medical Research and Department of Molecular and Translational Science, Monash University, Clayton, Australia.ORCID https://orcid.org/0000-0002-7587-8227

Funding

National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
Australian Government Research Training Program ScholarshipNational Health and Medical Research Council 1144887National Health and Medical Research Council 1144966National Health and Medical Research Council 2021247National Health and Medical Research Council GNT1144887National Health and Medical Research Council GNT1144966National Health and Medical Research Council GNT2021247NIDDK NIH HHS U2C DK119886NIH HHS OT2 OD030544
6 · The paper itself

Abstract

Germline epigenetic programming, including genomic imprinting, substantially influences offspring development. Polycomb Repressive Complex 2 (PRC2) plays an important role in Histone 3 Lysine 27 trimethylation (H3K27me3)-dependent imprinting, loss of which leads to growth and developmental changes in mouse offspring. In this study, we show that offspring from mouse oocytes lacking the PRC2 protein Embryonic Ectoderm Development (EED) were initially developmentally delayed, characterised by low blastocyst cell counts and substantial growth delay in mid-gestation embryos. This initial developmental delay was resolved as offspring underwent accelerated fetal development and growth in late gestation resulting in offspring that were similar stage and weight to controls at birth. The accelerated development and growth in offspring from

Indexed as

Genomic ImprintingAmino Acid Transport System AAnimalsFemaleFetal DevelopmentMiceOocytesPlacentaPolycomb Repressive Complex 2PregnancyAmino Acid Transport System AEed protein, mousePolycomb Repressive Complex 2Slc38a4 protein, mousedevelopmental biologyepigeneticfetal growthgeneticsgenomicsinheritancemouseoocyteplacentapolycomb

Identifiers

PMID38813868
PMCPMC11139480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.