Evidence map›Paper›PMID 38813607›Full record

ArticleAdvances in physiology education2024

Upskilling the cell therapy manufacturing workforce: design, implementation, and evaluation of a massive open online course.

Mingyu Yang, Flora J Keumurian, Caleb Neufeld, Elizabeth Skrip, John Duguid, Humberto Vega-Mercado, Reeta P Rao, Marsha W Rolle, Stacy L Springs, Jacqueline M Wolfrum and 2 more

Abstract read
In one paragraph

Article in Advances in physiology education, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mingyu YangHarvard-MIT Division of Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.ORCID 0000-0003-2558-7074
Flora J KeumurianCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.
Caleb NeufeldCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.
Elizabeth SkripCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.
John DuguidResearch and Development, Vericel Corporation, Cambridge, Massachusetts, United States.
Humberto Vega-MercadoBrystol Myers Squibb, Warren, New Jersey, United States.
Reeta P RaoDepartment of Biology & Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, United States.
Marsha W RolleDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, United States.
Stacy L SpringsCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.
Jacqueline M WolfrumCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.ORCID 0000-0002-9125-828X
Paul W BaroneCenter for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.ORCID 0000-0001-6802-6846
Krystyn J Van VlietDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States.

Funding

DOC | NIST | National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL)Hugh Hampton Young Memorial FellowshipMichael (1949) and Sonya Koerner Professorship
6 · The paper itself

Abstract

Cell therapies have gained prominence as a promising therapeutic modality for treating a range of diseases. Despite the recent clinical successes of cell therapy products, very few formal training programs exist for cell therapy manufacturing. To meet the demand for a well-trained workforce, we assembled a team of university researchers and industry professionals to develop an online course on the principles and practice of cell therapy manufacturing. The course covers the basic cell and systems physiology underlying cell therapy products, in addition to explaining end-to-end manufacturing from cell acquisition through to patient treatment, industrialization, and regulatory processes. As of September 2023, >10,000 learners have enrolled in the course, and >90% of respondents to the course exit survey indicated that they were "very likely" or "likely" to recommend the course to a peer. In this article, we discuss our experience in the collaborative design and implementation of the online course as well as lessons learned from quantitative and qualitative student feedback. We believe that this course can serve as a model for how academia and industry can collaborate to create innovative, scalable training programs to meet the demands of the modern biotechnology workforce.

Indexed as

Cell- and Tissue-Based TherapyEducation, DistanceCurriculumHumansUniversitiescell therapyindustryMOOCupskilling

Identifiers

PMID38813607
PMCPMC11684858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.